Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15966849 | 0.87 | AHR (0.41) | ALDH1A1TP53DDB1CRBNPDK2 | |
| SCHEMBL10952280 | 0.82 | ALDH1A1 (0.37) | ALDH1A1ALOX15GAATSHR | |
| SCHEMBL11368672 | 0.81 | DAO (0.40) | ALDH1A1MEN1KMT2ACA12CA1 | |
| SCHEMBL117727 | 0.80 | CACNB4 (0.40) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL11094086 | 0.79 | HTR1A (0.34) | ALDH1A1MEN1KMT2AGAAHTR2C | |
| SCHEMBL1321330 | 0.78 | HTR2C (0.46) | ALDH1A1MEN1KMT2ACA12CA1 | |
| SCHEMBL24112722 | 0.77 | MEN1 (0.42) | ALDH1A1MEN1KMT2ACA12CA1 | |
| SCHEMBL24112851 | 0.77 | MEN1 (0.42) | ALDH1A1MEN1KMT2ACA12CA1 | |
| SCHEMBL1319444 | 0.77 | TGM2 (0.39) | — | |
| SCHEMBL10711888 | 0.76 | BRD4 (0.40) | ALDH1A1HTR2BGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242934-B2 | Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses | BAYER CROPSCIENCE AG (DE) | 2016-01-26 | — | — | US | disclosed |
| EP-2424835-B1 | METHOD FOR PRODUCING OXINDOLES AND ORTHO-SUBSTITUTED ANILINES | BAYER IP GMBH (DE) | 2015-07-01 | — | — | EP | disclosed |
| US-20130281711-A1 | PROCESS FOR THE PREPARATION OF OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THEIR USE AS INTERMEDIATES FOR SYNTHESES | BAYER CROPSCIENCE AG (DE) | 2013-10-24 | — | — | US | disclosed |
| US-8563749-B2 | Process for preparing substituted 1,3-dihydro-2H-indol-2-ones | BAYER CROPSCIENCE AG (DE) | 2013-10-22 | — | — | US | disclosed |
| US-8492590-B2 | Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses | BAYER CROPSCIENCE AG (DE) | 2013-07-23 | — | — | US | disclosed |
| EP-2569283-A1 | PROCESS FOR PREPARING SUBSTITUTED 1,3-DIHYDRO-2H-INDOL-2-ONES | Bayer Intellectual Property GmbH (DE) | 2013-03-20 | — | — | EP | disclosed |
| CN-102985406-A | Process for preparing substituted 1,3-dihydro-2h-indol-2-ones | BAYER CROPSCIENCE AG | 2013-03-20 | — | — | CN | disclosed |
| WO-2012028162-A1 | PROCESS FOR PREPARING OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THE USE THEREOF AS INTERMEDIATES FOR SYNTHESES | BAYER CROPSCIENCE AG (DE) | 2012-03-08 | — | — | WO | disclosed |
| EP-2424835-A1 | METHOD FOR PRODUCING OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THE USE THEREOF AS INTERMEDIATE PRODUCTS FOR SYNTHESES | Bayer CropScience AG (DE) | 2012-03-07 | — | — | EP | disclosed |
| US-20110275832-A1 | Process for Preparing Substituted 1,3-dihydro-2H-indol-2-ones | BAYER CROPSCIENCE AG (DE) | 2011-11-10 | — | — | US | disclosed |
| WO-2010127786-A1 | METHOD FOR PRODUCING OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THE USE THEREOF AS INTERMEDIATE PRODUCTS FOR SYNTHESES | BAYER CROPSCIENCE AG (DE) | 2010-11-11 | — | — | WO | disclosed |
| EP-2246326-A1 | Method for producing oxindoles and ortho-substituted anilines and their use as intermediate products for syntheses | Bayer CropScience AG (DE) | 2010-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281711-A1 | PROCESS FOR THE PREPARATION OF OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THEIR USE AS INTERMEDIATES FOR SYNTHESES | TH, OXSR1, AOX1 | ALDH1A1 634/4885MEN1 3478/4885KMT2A 1699/4885 |
| US-20110275832-A1 | Process for Preparing Substituted 1,3-dihydro-2H-indol-2-ones | IDO1, IDO2, TDO2 | ALDH1A1 418/4885MEN1 4347/4885KMT2A 2950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.