Sugi Predict

Sugi Predict / Compounds / SCHEMBL1597773

SCHEMBL1597773

SCHEMBL1597773

CCOC(=O)C(Cl)Cc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP8 P22894 2/20 0.58
▸ PIN1 Q13526 1/20 0.49
▸ ALDH1A1 P00352 2/20 0.48
▸ EPHX2 P34913 1/20 0.48
▸ PPARG P37231 1/20 0.48
▸ TP53 P04637 1/20 0.48
▸ MEN1 O00255 1/20 0.47
▸ NPC1 O15118 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ L3MBTL1 Q9Y468 3/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ NPY1R P25929 1/20 0.47
▸ NPY2R P49146 1/20 0.47
▸ LMNA P02545 2/20 0.47
▸ POLB P06746 1/20 0.46
▸ HSD17B10 Q99714 1/20 0.46
▸ HPRT1 P00492 1/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ MAPT P10636 1/20 0.45
▸ PKM P14618 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11659027 0.87 LMNA (0.53) MMP8PPARGL3MBTL1LMNA
SCHEMBL7492211 0.87 L3MBTL1 (0.64) ALDH1A1PPARGL3MBTL1LMNA
SCHEMBL31408753 0.86 LMNA (0.50) MMP8ALDH1A1PPARGNPC1L3MBTL1
SCHEMBL11654791 0.85 LMNA (0.58) ALDH1A1PPARGMEN1NPC1KMT2A
SCHEMBL9557702 0.84 ALDH1A1 (0.58) ALDH1A1KMT2AL3MBTL1LMNAPOLB
SCHEMBL9557711 0.84 ALDH1A1 (0.58) ALDH1A1KMT2AL3MBTL1LMNAPOLB
SCHEMBL3204956 0.84 ATM (0.53) MMP8ALDH1A1MEN1NPC1KMT2A
SCHEMBL8895434 0.83 MMP8 (0.41) MMP8PIN1ALDH1A1EPHX2PPARG
Ammonia Solution, Strong SCHEMBL20513680 0.82 ATM (0.51) MMP8ALDH1A1MEN1NPC1KMT2A
SCHEMBL31408748 0.82 TSHR (0.56) MMP8ALDH1A1NPC1HSD17B10CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115894195-B Method for preparing 1-aryl-3-substituted acetone compounds and intermediate 迈克斯(如东)化工有限公司 2024-12-31 — — CN disclosed
CN-115894205-B Method for preparing 1-phenyl-3- (3-trifluoromethyl phenyl) -2-propanone, intermediate and application thereof 迈克斯(如东)化工有限公司 2024-11-29 — — CN disclosed
CN-115894205-A Method for preparing 1-phenyl-3- (3-trifluoromethylphenyl) -2-acetone, intermediate and application thereof 迈克斯(如东)化工有限公司 2023-04-04 — — CN disclosed
CN-115894195-A Method for preparing 1-aryl-3-substituted acetone compound and intermediate 迈克斯(如东)化工有限公司 2023-04-04 — — CN disclosed
EP-2427435-B1 SUBSTITUTED PHENYLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS MEDIFRON DBT INC (KR) 2017-06-14 — — EP disclosed
US-9624209-B2 Substituted phenylureas and phenylamides as vanilloid receptor ligands GRUENENTHAL GMBH (DE) 2017-04-18 — — US disclosed
US-9624209-B2 Substituted phenylureas and phenylamides as vanilloid receptor ligands GRUENENTHAL GMBH (DE) 2017-04-18 — — US disclosed
US-9120756-B2 Substituted phenylureas and phenylamides as vanilloid receptor ligands GRUENENTHAL GMBH (DE) 2015-09-01 — — US disclosed
US-9120756-B2 Substituted phenylureas and phenylamides as vanilloid receptor ligands GRUENENTHAL GMBH (DE) 2015-09-01 — — US disclosed
US-20150099728-A1 Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands MEDIFRON DBT INC. (KR) 2015-04-09 — — US disclosed
EP-1833805-A1 NEW 3-PHENYLPROPIONIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES Adamed SP. Z O.O. (PL) 2007-09-19 — — EP disclosed
US-20070161799-A1 3-Phenylpropionic acid derivatives ADAMED, SP. Z O.O. (PL) 2007-07-12 — — US disclosed
US-7220766-B2 3-phenylpropionic acid derivatives ADAMED, SP. Z.O.O. (PL) 2007-05-22 — — US disclosed
US-20070088061-A1 New 3-phenylpropionic acid derivatives ADAMED, SP. Z.O.O. (PL) 2007-04-19 — — US disclosed
WO-2006077206-A1 NEW 3-PHENYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR- GAMMA REZEPTOR LIGANDEN ADAMED SP. Z O.O. (PL) 2006-07-27 — — WO disclosed
WO-2006077217-A1 NEW 3-PHENYLPROPIONIC ACID DERIVATIVES ADAMED SP. Z O.O. (PL) 2006-07-27 — — WO disclosed
US-20060160870-A1 3-phenylpropionic acid derivatives ADAMED, SP. Z.O.O. (PL) 2006-07-20 — — US disclosed
US-20060160868-A1 3-Phenylpropionic acid derivatives ADAMED, SP. Z.O.O. (PL) 2006-07-20 — — US disclosed
WO-2006067086-A1 NEW 3-PHENYLPROPIONIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES ADAMED SP. Z O.O. (PL) 2006-06-29 — — WO disclosed
US-4705650-A DEACYLATION RHONE-POULENC SANTE (FR) 1987-11-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070088061-A1 New 3-phenylpropionic acid derivatives PPARA, PPARD, PPARG MMP8 4556/4885PIN1 2707/4885ALDH1A1 957/4885
US-20150099728-A1 Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands TRPV1, TRPV5, TRPV6 MMP8 4740/4885PIN1 2039/4885ALDH1A1 2943/4885
US-20070161799-A1 3-Phenylpropionic acid derivatives PAOX, PPARA, PPARG MMP8 2532/4885PIN1 3222/4885ALDH1A1 714/4885
US-20060160870-A1 3-phenylpropionic acid derivatives PPARA, PPARG, PPARD MMP8 4207/4885PIN1 2407/4885ALDH1A1 846/4885
US-20060160868-A1 3-Phenylpropionic acid derivatives PPARA, PPARG, PPARD MMP8 4149/4885PIN1 2064/4885ALDH1A1 844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.