Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004271 | 0.91 | RIPK1 (0.45) | RIPK1NTRK1MEN1KMT2APIK3CA | |
| SCHEMBL16004274 | 0.90 | RIPK1 (0.46) | RIPK1MEN1KMT2APIK3CACREBBP | |
| SCHEMBL16004285 | 0.89 | CREBBP (0.54) | CREBBP | |
| SCHEMBL16004236 | 0.89 | KDM4E (0.43) | RIPK1MEN1KMT2APIK3CACREBBP | |
| SCHEMBL16004052 | 0.87 | PIK3CA (0.52) | RIPK1PIK3CAALDH1A1GAAHPGD | |
| SCHEMBL16004249 | 0.87 | RIPK1 (0.41) | RIPK1MEN1KMT2APIK3CACREBBP | |
| SCHEMBL16004054 | 0.86 | PIK3CA (0.49) | RIPK1MEN1KMT2APIK3CACREBBP | |
| SCHEMBL16004233 | 0.86 | GPR142 (0.47) | RIPK1KMT2APIK3CAALDH1A1GAA | |
| SCHEMBL16004055 | 0.86 | PIK3CA (0.49) | RIPK1MEN1KMT2APIK3CAGPR142 | |
| SCHEMBL16004053 | 0.85 | RIPK1 (0.49) | RIPK1PIK3CAALDH1A1GAAGPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |