Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004269 | 0.91 | RIPK1 (0.46) | RIPK1MEN1KMT2ANTRK1PIK3CA | |
| SCHEMBL16004283 | 0.88 | CREBBP (0.52) | CREBBP | |
| SCHEMBL16004274 | 0.85 | RIPK1 (0.46) | RIPK1MEN1KMT2APIK3CACREBBP | |
| SCHEMBL16004243 | 0.84 | PIK3CA (0.40) | RIPK1MEN1KMT2APIK3CACREBBP | |
| SCHEMBL16004232 | 0.82 | PIK3CA (0.49) | RIPK1PIK3CAAOC3GAAHPGD | |
| SCHEMBL16004285 | 0.80 | CREBBP (0.54) | CREBBP | |
| SCHEMBL16004236 | 0.80 | KDM4E (0.43) | RIPK1MEN1KMT2APIK3CACREBBP | |
| SCHEMBL16004249 | 0.78 | RIPK1 (0.41) | RIPK1MEN1KMT2APIK3CACREBBP | |
| SCHEMBL16004052 | 0.78 | PIK3CA (0.52) | RIPK1PIK3CAAOC3ALDH1A1GAA | |
| SCHEMBL16004055 | 0.78 | PIK3CA (0.49) | RIPK1MEN1KMT2APIK3CAGPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |