Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | USP9X | Q93008 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004274 | 0.87 | RIPK1 (0.46) | GPR142KMT2AHPGDALDH1A1GAA | |
| SCHEMBL16004052 | 0.86 | PIK3CA (0.52) | HPGDALDH1A1GAATSHRRIPK1 | |
| SCHEMBL16004236 | 0.86 | KDM4E (0.43) | GPR142KMT2AHPGDALDH1A1GAA | |
| SCHEMBL16004269 | 0.86 | RIPK1 (0.46) | GPR142KMT2AHPGDALDH1A1GAA | |
| SCHEMBL16004068 | 0.85 | MAPT (0.49) | GPR142NPC1KMT2AHPGDALDH1A1 | |
| SCHEMBL16004249 | 0.84 | RIPK1 (0.41) | GPR142KMT2ARIPK1PIK3CA | |
| SCHEMBL16004278 | 0.84 | GPR142 (0.59) | GPR142NPC1TSHRRAB9APOLB | |
| SCHEMBL16004285 | 0.82 | CREBBP (0.54) | — | |
| SCHEMBL16004060 | 0.81 | LMNA (0.43) | GPR142NPC1ALDH1A1RIPK1PIK3CA | |
| SCHEMBL16004117 | 0.81 | KDM4E (0.43) | GPR142KMT2AALDH1A1MAPTRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |