Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17407528 | 0.85 | NTRK1 (0.40) | HTR2AKCNH2 | |
| SCHEMBL14436458 | 0.85 | SLC6A4 (0.38) | HTR2ASLC6A4KCNH2SCN9A | |
| SCHEMBL19057964 | 0.82 | AR (0.41) | — | |
| SCHEMBL16004762 | 0.72 | SLC6A4 (0.37) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL19057963 | 0.70 | SLC6A4 (0.41) | HTR2ASLC6A4KCNH2SCN9A | |
| SCHEMBL19057972 | 0.68 | AR (0.42) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL13924849 | 0.67 | SLC6A4 (0.46) | HTR2ASLC6A4KCNH2 | |
| SCHEMBL14437176 | 0.66 | PLA2G7 (0.41) | — | |
| SCHEMBL13274176 | 0.66 | SCN9A (0.43) | KCNH2SCN9A | |
| SCHEMBL14435933 | 0.63 | PLA2G7 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961744-B1 | INTERMEDIATES FOR USE IN THE PREPARATION OF INDAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | ARRAY BIOPHARMA INC (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2014134313-A1 | INTERMEDIATES FOR USE IN THE PREPARATION OF INDAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | ARRAY BIOPHARMA INC. (US) | 2014-09-04 | — | — | WO | disclosed |