Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.46 |
| ▸ | HTR2A | P28223 | 15/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14436458 | 0.72 | SLC6A4 (0.38) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL16004762 | 0.70 | SLC6A4 (0.37) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL19057972 | 0.68 | AR (0.42) | SLC6A4HTR2AKCNH2 | |
| SCHEMBL16004751 | 0.67 | HTR2A (0.37) | SLC6A4HTR2AKCNH2 | |
| SCHEMBL18359310 | 0.67 | PTGS2 (0.34) | MAPK8 | |
| SCHEMBL12298683 | 0.67 | HTR2A (0.48) | SLC6A4HTR2AKCNH2 | |
| SCHEMBL19057964 | 0.65 | AR (0.41) | — | |
| SCHEMBL7642609 | 0.64 | HTR2A (0.74) | SLC6A4HTR2AKCNH2 | |
| SCHEMBL14437176 | 0.64 | PLA2G7 (0.41) | — | |
| SCHEMBL13924873 | 0.64 | SLC6A4 (0.47) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2039685-A2 | Heterobicyclic compounds as P38 inhibitors | Array Biopharma, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1997809-A2 | Indazole, benzoxazole and pyrazolopyridine derivatives for medical use | Array Biopharma Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| EP-1997810-A2 | Indazole, benzoxazole and pyrazolopyridine derivatives for medical use | Array Biopharma Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| EP-1997811-A2 | Indazole, benzoxazole and pyrazolopyridine derivatives as P38 kinase inhibitors | Array Biopharma Inc. (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2004078116-A9 | P38 INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2008-09-12 | — | — | WO | disclosed |