Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16012065 | 0.92 | VNN1 (0.44) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL17797438 | 0.88 | VNN1 (0.45) | MAPTRAB9AALDH1A1VNN1TRPV4 | |
| SCHEMBL14802053 | 0.84 | JAK2 (0.51) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL14801946 | 0.83 | CA1 (0.47) | KMT2AMEN1ALDH1A1NPSR1VNN1 | |
| SCHEMBL18880601 | 0.82 | POLB (0.47) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL18830440 | 0.79 | ALDH1A1 (0.41) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL14801537 | 0.79 | HCAR3 (0.43) | KMT2AMEN1VNN1TP53 | |
| SCHEMBL16012133 | 0.77 | DRD2 (0.44) | MAPTRAB9AALDH1A1NPSR1VNN1 | |
| SCHEMBL11565569 | 0.77 | SMN1; SMN2 (0.56) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL16011866 | 0.76 | VNN1 (0.42) | MAPTRAB9AALDH1A1VNN1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964630-B9 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2017-08-09 | — | — | EP | disclosed |
| US-9656992-B2 | Pyrimidine compounds for the treatment of hepatitis C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-23 | — | — | US | disclosed |
| EP-2964630-B1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2017-05-10 | — | — | EP | disclosed |
| US-20160159769-A1 | Pyrimidine Compounds for the Treatment of Hepatitis C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-09 | — | — | US | disclosed |
| EP-2964630-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | Bristol-Myers Squibb Company (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014138199-A1 | PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159769-A1 | Pyrimidine Compounds for the Treatment of Hepatitis C | TYMP, UMPS, NUDT1 | JAK2 543/4885JAK1 450/4885TYK2 1695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.