Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.81 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.81 |
| ▸ | CES1 | P23141 | 4/20 | 0.81 |
| ▸ | MAPT | P10636 | 4/20 | 0.81 |
| ▸ | CES2 | O00748 | 3/20 | 0.81 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.81 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.81 |
| ▸ | KDM1A | O60341 | 2/20 | 0.81 |
| ▸ | BLM | P54132 | 2/20 | 0.81 |
| ▸ | EED | O75530 | 2/20 | 0.81 |
| ▸ | POLB | P06746 | 2/20 | 0.81 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.81 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.81 |
| ▸ | NSD1 | Q96L73 | 2/20 | 0.81 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.81 |
| ▸ | IDO1 | P14902 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29411323 | 1.00 | HIF1A (0.81) | HIF1AEPAS1TDP1CES1MAPT | |
| Tanshinone I SCHEMBL244391 | 0.90 | TDP1 (1.00) | HIF1AEPAS1TDP1CES1MAPT | |
| Tanshinone I SCHEMBL14993883 | 0.90 | TDP1 (1.00) | HIF1AEPAS1TDP1CES1MAPT | |
| Isotanshinone Ii SCHEMBL30035659 | 0.88 | HIF1A (0.81) | HIF1AEPAS1TDP1CES1MAPT | |
| Tanshinone I SCHEMBL2564448 | 0.88 | TDP1 (0.97) | HIF1AEPAS1TDP1CES1MAPT | |
| Tanshinone I SCHEMBL3664228 | 0.85 | TDP1 (0.89) | HIF1AEPAS1TDP1CES1MAPT | |
| Tanshinone I SCHEMBL728081 | 0.77 | EED (0.73) | HIF1AEPAS1TDP1CES1MAPT | |
| SCHEMBL16152288 | 0.75 | TDP1 (0.73) | HIF1AEPAS1TDP1CES1MAPT | |
| SCHEMBL29520853 | 0.75 | TDP1 (0.73) | HIF1AEPAS1TDP1CES1MAPT | |
| SCHEMBL30381335 | 0.75 | EED (0.73) | HIF1AEPAS1TDP1CES1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014138357-A1 | NOVEL TASHINONE DRUGS FOR ALZHEIMER DISEASE | THE UNIVERSITY OF AKRON (US) | 2014-09-12 | — | — | WO | disclosed |