Tanshinone I

Tanshinone I

SCHEMBL244391

Cc1coc2c1C(=O)C(=O)c1c-2ccc2c(C)cccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 4/20 1.00
HIF1A Q16665 4/20 1.00
EPAS1 Q99814 4/20 1.00
CES1 P23141 4/20 1.00
EED O75530 4/20 1.00
SUZ12 Q15022 4/20 1.00
EZH2 Q15910 4/20 1.00
CES2 O00748 3/20 1.00
MAPT P10636 3/20 1.00
PTPN6 P29350 3/20 1.00
PTPN11 Q06124 3/20 1.00
KDM1A O60341 2/20 1.00
BLM P54132 2/20 1.00
POLB P06746 2/20 1.00
NSD1 Q96L73 2/20 1.00
HDAC6 Q9UBN7 1/20 1.00
NQO1 P15559 4/20 0.54
POR P16435 4/20 0.54
IDO1 P14902 8/20 0.51
MEN1 O00255 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tanshinone I SCHEMBL14993883 1.00 TDP1 (1.00) TDP1HIF1AEPAS1CES1EED
Tanshinone I SCHEMBL2564448 0.98 TDP1 (0.97) TDP1HIF1AEPAS1CES1EED
Tanshinone I SCHEMBL3664228 0.94 TDP1 (0.89) TDP1HIF1AEPAS1CES1EED
Isotanshinone Ii SCHEMBL30035659 0.90 HIF1A (0.81) TDP1HIF1AEPAS1CES1EED
SCHEMBL29411323 0.90 HIF1A (0.81) TDP1HIF1AEPAS1CES1EED
SCHEMBL16023778 0.90 HIF1A (0.81) TDP1HIF1AEPAS1CES1EED
Tanshinone I SCHEMBL728081 0.86 EED (0.73) TDP1HIF1AEPAS1CES1EED
SCHEMBL16152288 0.85 TDP1 (0.73) TDP1HIF1AEPAS1CES1EED
SCHEMBL30381335 0.85 EED (0.73) TDP1HIF1AEPAS1CES1EED
SCHEMBL29520853 0.85 TDP1 (0.73) TDP1HIF1AEPAS1CES1EED

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9685 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122081339-A SmHRD3A gene and application thereof in improving tanshinone content in salvia miltiorrhiza bunge 2026-05-26 CN claimed
WO-2026102914-A1 TRADITIONAL CHINESE MEDICINE COMPOSITION AND USE THEREOF 贵阳新天药业股份有限公司 2026-05-21 WO claimed
CN-122067093-A Multi-source remote sensing image-based dual-target prediction method for yield-quality of red sage root 河南大学 2026-05-19 CN claimed
CN-122031290-A Percutaneous permeation promoting system and preparation method and application thereof 北京工商大学 2026-05-15 CN claimed
CN-122031426-A Colon targeted delivery Chinese medicinal microcapsule preparation for nephrosis and its preparation method 南方医科大学 2026-05-15 CN claimed
EP-4714440-A2 A HEALING HERBAL-MINERAL COMPOSITION WITH ENHANCED EFFECTS Kurek, Janusz (PL) 2026-03-25 EP claimed
EP-4677998-A1 A METHOD OF PRODUCING A PLANT WITH AN INCREASED DENSITY OF GLANDULAR TRICHOMES AND/OR AN INCREASED PRODUCTION OF METABOLITES Institut National de la Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR) 2026-01-14 EP claimed
US-20250262230-A1 HMGB1 Inhibitors for Treatment of APOE4-related Tauopathies including Alzheimer’s Disease THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-08-21 US claimed
EP-4587011-A1 COMBINATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING A PI3K/AKT/MTOR PATHWAY INHIBITING COMPOUND Royal Holloway & Bedford New College (GB) 2025-07-23 EP claimed
EP-4580612-A1 USE OF NRF2 ACTIVATORS FOR THE TREATMENT OF CEREBRAL SMALL VESSEL DISEASE Institut National de la Santé et de la Recherche Médicale (FR) 2025-07-09 EP claimed
CN-1293054-A Medicine for treating hepatism and its preparing process DENG KAIZHONG (CN) 2001-05-02 CN claimed
CN-1277840-A Tanshinone solid disperser and its prepn. method WEILAI MODERN SCIENCE & TECH D (CN) 2000-12-27 CN claimed
CN-1264580-A Application of tanshinone in preparing medicine for treating tumor HOSPITAL NO 1 ATTACHED TO HUAX (CN) 2000-08-30 CN claimed
CN-1256142-A Supercritical CO2 extraction process of the active component in red sage as one Chinese medicine material SOUTHWEST CHINA DESIGN INST OF (CN) 2000-06-14 CN claimed
US-5904923-A LIPOPHILIC EXTRACT OF ROOTS OF SALVIA MILTIORRHYZA PLANT INDENA S.P.A. (IT) 1999-05-18 US claimed
CN-1184429-A Pharmaceutical compositions for the treatment of alcohol addiction INDENA SPA (IT) 1998-06-10 CN claimed
EP-0824356-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ALCOHOL ADDICTION INDENA S.p.A. (IT) 1998-02-25 EP claimed
US-5589182-A AQUEOUS EXTRACTS OF TISSUE OF SPECIFIC CHINESE PLANTS AND HERBS TASHIRO RENKI (JP) 1996-12-31 US claimed
WO-1996035441-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ALCOHOL ADDICTION INDENA S.P.A. (IT) 1996-11-14 WO claimed
EP-0257887-A2 Ophthalmic compositions HOUSTON BIOTECHNOLOGY INCORPORATED (US) 1988-03-02 EP claimed