Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3416823 | 0.82 | HSD11B1 (0.41) | ALDH1A1NOTUMHSD11B1HSD17B10AR | |
| SCHEMBL21354744 | 0.79 | CYP3A4 (0.33) | TDP1 | |
| SCHEMBL24092 | 0.77 | CA2 (0.39) | ALDH1A1TDP1CA2 | |
| SCHEMBL13728893 | 0.77 | HSD11B1 (0.37) | P2RX7NOTUMHSD11B1AR | |
| SCHEMBL6513958 | 0.77 | ACHE (0.35) | ALDH1A1POLBKDM4EHSD17B10LMNA | |
| SCHEMBL20955825 | 0.76 | — | — | |
| SCHEMBL82438 | 0.74 | TDP1 (0.34) | ALDH1A1POLBTDP1L3MBTL1NOTUM | |
| SCHEMBL81363 | 0.74 | ALDH1A1 (0.39) | ALDH1A1POLBTDP1L3MBTL1HSD11B1 | |
| SCHEMBL13730506 | 0.73 | AR (0.46) | NOTUMIDO1AR | |
| SCHEMBL13730818 | 0.73 | HSD11B1 (0.39) | TDP1HSD11B1KDM4EAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110770214-B | Heterocyclic P2X7 antagonists | 布雷耶疗法有限公司 | 2024-03-29 | — | — | CN | claimed |
| US-20240002344-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR HISTONE LYSINE DEMETHYLASE INHIBITION | FIBROGEN, INC. | 2024-01-04 | — | — | US | claimed |
| WO-2023239768-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION (US) | 2023-12-14 | — | — | WO | claimed |
| US-20230399342-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | INCYTE CORPORATION | 2023-12-14 | — | — | US | claimed |
| EP-4204400-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR HISTONE LYSINE DEMETHYLASE INHIBITION | Fibrogen, Inc. (US) | 2023-07-05 | — | — | EP | claimed |
| CN-110536892-B | Novel bicyclic pyrazole derivatives | 拜耳动物保健有限责任公司 | 2023-05-12 | — | — | CN | claimed |
| US-11623919-B2 | Heterocyclic P2X7 antagonists | BREYE THERAPEUTICS APS (DK) | 2023-04-11 | — | — | US | claimed |
| CN-110003200-B | P2X7 modulators | 詹森药业有限公司 | 2021-11-26 | — | — | CN | claimed |
| US-11130768-B2 | Bicyclic pyrazole derivatives | BAYER ANIMAL HEALTH GMBH (DE) | 2021-09-28 | — | — | US | claimed |
| EP-3091970-B1 | LXR AGONISTS AND USES THEREOF | RGENIX INC (US) | 2020-10-28 | — | — | EP | claimed |
| US-4540429-A | 4-Phenyl-1,2,3-thiadiazoles as herbicide extenders | STAUFFER CHEMICAL COMPANY (US) | 1985-09-10 | — | — | US | claimed |
| US-4512989-A | IMIDOESTERS OR IMIDOTHIOESTERS | HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) | 1985-04-23 | — | — | US | claimed |
| EP-0062773-B1 | 4-Phenyl-1,2,3-thiadiazoles as herbicide extenders | STAUFFER CHEMICAL COMPANY (US) | 1984-12-05 | — | — | EP | claimed |
| EP-0125803-A2 | Pharmaceutically active dihydropyridines | FISONS plc (GB) | 1984-11-21 | — | — | EP | claimed |
| EP-0118864-A1 | Pyrimidinyl derivatives | BAYER AG (DE) | 1984-09-19 | — | — | EP | claimed |
| EP-0116769-A1 | Dihydropyridines | Pfizer Limited (GB) | 1984-08-29 | — | — | EP | claimed |
| US-4391804-A | Imidazole derivatives and fungicidal composition containing the same | HOKKO CHEMICAL INDUSTRY COMPANY, LTD. (JP) | 1983-07-05 | — | — | US | claimed |
| EP-0062773-A1 | 4-Phenyl-1,2,3-thiadiazoles as herbicide extenders | STAUFFER CHEMICAL COMPANY (US) | 1982-10-20 | — | — | EP | claimed |
| US-4146386-A | Phthalic dianilides and their use as plant growth regulators | MONSANTO COMPANY (US) | 1979-03-27 | — | — | US | claimed |
| US-4016281-A | Tetralone and indanone compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) | 1977-04-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11623919-B2 | Heterocyclic P2X7 antagonists | P2RY1, P2RX1, P2RX3 | P2RX7 4/4885ALDH1A1 1689/4885POLB 4137/4885 |
| US-11130768-B2 | Bicyclic pyrazole derivatives | CYP1B1, CYP3A43, CYP3A5 | P2RX7 82/4885ALDH1A1 805/4885POLB 2003/4885 |
| US-20230399342-A1 | TRICYCLIC TRIAZOLO COMPOUNDS AS DGK INHIBITORS | DGKA, DGKI, DGKG | P2RX7 2750/4885ALDH1A1 4279/4885POLB 2276/4885 |
| US-20240002344-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR HISTONE LYSINE DEMETHYLASE INHIBITION | KDM5C, KDM5B, KDM5A | P2RX7 4287/4885ALDH1A1 2449/4885POLB 946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.