SCHEMBL1603232

SCHEMBL1603232

O=C(Oc1c(Br)cccc1Br)c1c2ccccc2nc2ccccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.42
MEN1 O00255 1/20 0.42
CDK9 P50750 1/20 0.42
DYRK1A Q13627 1/20 0.42
DYRK2 Q92630 1/20 0.42
DYRK1B Q9Y463 1/20 0.42
PDE10A Q9Y233 3/20 0.41
GRM2 Q14416 1/20 0.40
POLB P06746 2/20 0.40
MAPT P10636 5/20 0.39
KDM4E B2RXH2 3/20 0.39
GUSB P08236 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
DHODH Q02127 2/20 0.39
LMNA P02545 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
GLA P06280 2/20 0.39
HTT P42858 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8875118 0.82 SMN1; SMN2 (0.41) KMT2AMEN1PDE10AGRM2POLB
SCHEMBL7795326 0.81 KMT2A (0.44) KMT2AMEN1PDE10APOLBMAPT
SCHEMBL1054774 0.81 MEN1 (0.49) KMT2AMEN1PDE10APOLBMAPT
SCHEMBL38661829 0.81 MEN1 (0.49) KMT2AMEN1PDE10APOLBMAPT
SCHEMBL7049459 0.81 KMT2A (0.47) KMT2AMEN1CDK9DYRK1ADYRK2
SCHEMBL4623903 0.80 THRA (0.54)
SCHEMBL7048368 0.80 MEN1 (0.45) KMT2AMEN1PDE10APOLBMAPT
SCHEMBL12096583 0.79 PLA2G2A (0.46) KMT2AMEN1CDK9DYRK1ADYRK2
SCHEMBL5705535 0.78 MAPT (0.50) KMT2AMEN1PDE10APOLBMAPT
SCHEMBL1602466 0.78 BACE1 (0.41) KMT2AMEN1PDE10APOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110082279-A1 Chemiluminescent Compounds GEN-PROBE INCORPORATED (US) 2011-04-07 US disclosed
US-20110082279-A1 Chemiluminescent Compounds GEN-PROBE INCORPORATED (US) 2011-04-07 US disclosed
US-20110082279-A1 Chemiluminescent Compounds GEN-PROBE INCORPORATED (US) 2011-04-07 US disclosed
EP-1658503-B1 CHEMILUMINESCENT COMPOUNDS MOLECULAR LIGHT TECH RES LTD (GB) 2009-11-18 EP disclosed
US-20070166759-A1 Chemiluminescent compounds GEN-PROBE CARDIFF, LTD. (GB) 2007-07-19 US disclosed
US-20070166759-A1 Chemiluminescent compounds GEN-PROBE CARDIFF, LTD. (GB) 2007-07-19 US disclosed
US-20070166759-A1 Chemiluminescent compounds GEN-PROBE CARDIFF, LTD. (GB) 2007-07-19 US disclosed
EP-1658503-A1 CHEMILUMINESCENT COMPOUNDS Molecular Light Technology Research Limited (GB) 2006-05-24 EP disclosed
WO-2005022161-A1 CHEMILUMINESCENT COMPOUNDS MOLECULAR LIGHT TECHNOLOGY RESEARCH LIMITED (GB) 2005-03-10 WO disclosed
EP-0609885-B1 Acridinium compounds and conjugates thereof MOCHIDA PHARM CO LTD (JP) 2003-04-16 EP disclosed
US-5594112-A CHEMILUMINESCENCE LABEL MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1997-01-14 US disclosed
US-5438139-A Chemiluminescent; useful as immunolochemical, DNA probe and receptor bininding assays MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1995-08-01 US disclosed
EP-0609885-A1 Acridinium compounds and conjugates thereof MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1994-08-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070166759-A1 Chemiluminescent compounds CBR3, CBR1, LTC4S KMT2A 3854/4885MEN1 2101/4885CDK9 3431/4885
US-20110082279-A1 Chemiluminescent Compounds CBR3, LTC4S, CBR1 KMT2A 3896/4885MEN1 1714/4885CDK9 3642/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.