Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.77 |
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.74 |
| ▸ | CYP1A1 | P04798 | 8/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.66 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.66 |
| ▸ | F3 | P13726 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.66 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.66 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.66 |
| ▸ | MAOB | P27338 | 1/20 | 0.66 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29600034 | 1.00 | RAB9A (1.00) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL5646960 | 1.00 | RAB9A (1.00) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL13479662 | 0.94 | RAB9A (0.88) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL196640 | 0.87 | PFKFB3 (1.00) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL29458617 | 0.87 | PFKFB3 (1.00) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL979409 | 0.87 | CYP1B1 (0.83) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL7368933 | 0.87 | CYP1B1 (0.83) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL196639 | 0.87 | PFKFB3 (1.00) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL1321942 | 0.86 | RAB9A (0.76) | RAB9AMAPTKMT2APFKFB3CYP1B1 | |
| SCHEMBL6700090 | 0.86 | RAB9A (0.76) | RAB9AMAPTKMT2APFKFB3CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242144-B2 | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-08-14 | — | — | US | disclosed |
| US-20110082176-A1 | Stilbenes and Chalcones for the Prevention and Treatment of Cardiovascular Diseases | RESVERLOGIX CORP. | 2011-04-07 | — | — | US | disclosed |
| US-7846915-B2 | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases | Resverlogix Corporation (CA) | 2010-12-07 | — | — | US | disclosed |
| US-7279470-B2 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK A/S (DK) | 2007-10-09 | — | — | US | disclosed |
| US-20060205792-A1 | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases | HEPALINK (HONG KONG) LIMITED (HK) | 2006-09-14 | — | — | US | disclosed |
| WO-2006081658-A1 | IN SILICO SCREENING FOR SHBG BINDING LIGANDS VIA PHARMACOPHORE MODELS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2006-08-10 | — | — | WO | disclosed |
| US-7067517-B2 | Use of compounds for decreasing activity of hormone-sensitive lipase | NERO NORDISK A/S (DK) | 2006-06-27 | — | — | US | disclosed |
| WO-2006045010-A2 | STILBENES AND CHALCONES FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES | RESVERLOGIX CORP. (CA) | 2006-04-27 | — | — | WO | disclosed |
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| EP-1458375-A2 | COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | NOVO NORDISK A/S (DK) | 2003-09-04 | — | — | US | disclosed |
| WO-2003051842-A2 | COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166644-A1 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | LIPE, PNLIP, LPL | RAB9A 2926/4885MAPT 4693/4885KMT2A 4150/4885 |
| US-20060205792-A1 | Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases | APOB, APOL1, HDLBP | RAB9A 3696/4885MAPT 2177/4885KMT2A 3632/4885 |
| US-20030166690-A1 | Use of compounds for decreasing activity of hormone-sensitive | LIPE, PNLIP, LPL | RAB9A 3386/4885MAPT 4668/4885KMT2A 4322/4885 |
| US-20110082176-A1 | Stilbenes and Chalcones for the Prevention and Treatment of Cardiovascular Diseases | APOB, APOL1, HDLBP | RAB9A 3696/4885MAPT 2177/4885KMT2A 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.