Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.61 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 11/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16047515 | 0.93 | PTGS2 (0.62) | PTGS2EPAS1BRD4EP300SLC22A12 | |
| SCHEMBL16045757 | 0.92 | PTGS2 (0.55) | PTGS2EPAS1BRD4EP300MAPK8 | |
| SCHEMBL29548745 | 0.85 | PTGS2 (0.51) | PTGS2EPAS1BRD4EP300MAPK8 | |
| SCHEMBL28721123 | 0.85 | PTGS2 (0.51) | PTGS2EPAS1BRD4EP300MAPK8 | |
| SCHEMBL16651668 | 0.83 | EPAS1 (0.55) | PTGS2EPAS1BRD4EP300 | |
| SCHEMBL29549377 | 0.82 | BRD4 (0.51) | PTGS2EPAS1BRD4EP300 | |
| SCHEMBL28720338 | 0.82 | BRD4 (0.51) | PTGS2EPAS1BRD4EP300 | |
| SCHEMBL8524487 | 0.81 | PTGS2 (0.59) | PTGS2EPAS1BRD4EP300CCR2 | |
| SCHEMBL10416533 | 0.80 | PTGS2 (0.59) | PTGS2EPAS1BRD4EP300SLC22A12 | |
| SCHEMBL8107798 | 0.80 | PTGS2 (0.56) | PTGS2EPAS1BRD4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160237084-A1 | DIHYDRO-PYRROLOPYRIDINONE INHIBITORS | ABBVIE INC (US) | 2016-08-18 | — | — | US | disclosed |
| US-9321764-B2 | Dihydro-pyrrolopyridinone inhibitors | ABBVIE INC. (US) | 2016-04-26 | — | — | US | disclosed |
| EP-2970276-A1 | DIHYDRO-PYRROLOPYRIDINONE BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014165143-A1 | DIHYDRO-PYRROLOPYRIDINONE BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| US-20140275026-A1 | DIHYDRO-PYRROLOPYRIDINONE INHIBITORS | ABBVIE INC. | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237084-A1 | DIHYDRO-PYRROLOPYRIDINONE INHIBITORS | DPYD, QDPR, DHFR | PTGS2 840/4885EPAS1 1091/4885BRD4 676/4885 |
| US-20140275026-A1 | DIHYDRO-PYRROLOPYRIDINONE INHIBITORS | DPYD, QDPR, DHFR | PTGS2 840/4885EPAS1 1091/4885BRD4 676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.