Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.43 |
| ▸ | LPL | P06858 | 7/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | F11 | P03951 | 2/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28490255 | 0.83 | CA1 (0.44) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL16908889 | 0.81 | CA1 (0.40) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL22657406 | 0.79 | AAK1 (0.43) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL1534612 | 0.78 | CA1 (0.43) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL28817158 | 0.76 | AAK1 (0.38) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL16050350 | 0.76 | LPL (0.47) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL29257111 | 0.75 | LPL (0.46) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL28398971 | 0.75 | OPRM1 (0.65) | OPRM1OPRD1OPRK1DRD3DRD2 | |
| SCHEMBL6059 | 0.74 | GAA (0.49) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL22871651 | 0.73 | LIPG (0.54) | LIPGLPLCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970119-B1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |
| US-9650375-B2 | Indole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP. (US) | 2017-05-16 | — | — | US | disclosed |
| EP-2970119-A1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | Merck Sharp & Dohme Corp. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20160002224-A1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME LLC | 2016-01-07 | — | — | US | disclosed |
| WO-2014139388-A1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME CORP. (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002224-A1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | GPR119, PRKAG2, PRKAG1 | LIPG 179/4885LPL 415/4885OPRM1 3069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.