Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR1E | P28566 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16727225 | 0.82 | GPR84 (0.41) | GPR84ATMHTR1DHTR1BHTR2A | |
| SCHEMBL9333774 | 0.80 | MAOA (0.38) | GPR84MAOAATMHTR1DHTR1B | |
| SCHEMBL31386148 | 0.77 | HTR6 (0.49) | GPR84ATMHTR1DHTR1BHTR2A | |
| SCHEMBL16727226 | 0.77 | HTR6 (0.49) | GPR84ATMHTR1DHTR1BHTR2A | |
| SCHEMBL4418345 | 0.76 | ATM (0.48) | GPR84MAOAATMHTR1DHTR1B | |
| SCHEMBL16729373 | 0.74 | GPR84 (0.36) | GPR84ATMHTR1DHTR1BHTR2A | |
| SCHEMBL17452499 | 0.74 | HTR1A (0.56) | GPR84HTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL29951076 | 0.73 | CYP2A6 (0.47) | HTR1DHTR1BERN1HTR1AP2RX7 | |
| SCHEMBL321318 | 0.72 | HTR2A (0.54) | GPR84ATMHTR1DHTR1BHTR2A | |
| SCHEMBL32669245 | 0.71 | HTR1A (0.67) | MAOAHTR1DHTR1BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016138527-A1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE, INC. (US) | 2016-09-01 | — | — | WO | disclosed |
| WO-2014145403-A1 | SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | NANTBIO, INC. (US) | 2014-09-18 | — | — | WO | disclosed |