SCHEMBL160662

SCHEMBL160662

C1=Cc2ncccc2SC1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPK10 P53779 1/20 0.31
HSD17B10 Q99714 1/20 0.31
KDM4E B2RXH2 2/20 0.30
MAPT P10636 2/20 0.30
HDAC8 Q9BY41 1/20 0.30
GMNN O75496 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
HSP90AA1 P07900 1/20 0.30
MMP2 P08253 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
MMP9 P14780 1/20 0.30
TSHR P16473 1/20 0.30
NFKB1 P19838 1/20 0.30
MMP8 P22894 1/20 0.30
CCR1 P32246 1/20 0.30
THPO P40225 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30624470 1.00 ALOX15 (0.31) ALOX15ALDH1A1MAPK10HSD17B10KDM4E
SCHEMBL220456 0.71
SCHEMBL9940454 0.71
SCHEMBL31408049 0.68 MEN1 (0.32) ALDH1A1
SCHEMBL4513308 0.67
SCHEMBL29412638 0.67
SCHEMBL4237139 0.67
SCHEMBL26658123 0.65
SCHEMBL29569587 0.65 MEN1 (0.30) ALDH1A1
SCHEMBL44493 0.65 MEN1 (0.30) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 752 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110183397-B Method for preparing 1, 5-benzothiazine compound by catalysis of zirconocene dichloride 陕西师范大学 2022-08-23 CN claimed
WO-2015173035-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2015-11-19 WO claimed
US-8288529-B2 Geometric synthesis of porphyrin rods NORTH CAROLINA STATE UNIVERSITY (US) 2012-10-16 US claimed
US-8207329-B2 Synthesis of chlorins and phorbines with enhanced red spectral features NORTH CAROLINA STATE UNIVERSITY (US) 2012-06-26 US claimed
US-7799910-B2 Geometric synthesis of porphyrin rods NORTH CAROLINA STATE UNIVERSITY (US) 2010-09-21 US claimed
EP-1317443-B1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC (CA) 2009-01-14 EP claimed
US-20080090846-A1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS GENZYME CORPORATION 2008-04-17 US claimed
US-20070123510-A1 Guanidine derivatives ACTELION PHARMACEUTICALS LTD. (CH) 2007-05-31 US claimed
US-20050026942-A1 Chemokine receptor binding heterocyclic compounds ANORMED (CA) 2005-02-03 US claimed
EP-1317443-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC. (CA) 2003-06-11 EP claimed
US-20020147192-A1 Chemokine receptor binding heterocyclic compounds GENZYME CORPORATION 2002-10-10 US claimed
WO-2002022599-A2 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS ANORMED INC. (CA) 2002-03-21 WO claimed
EP-0227932-A1 Novel fused pyridine compounds, intermediates for the preparation of, and use of said compounds as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1987-07-08 EP claimed
EP-4735535-A2 COMPOUNDS INCLUDING A WATER-SOLUBILIZATION MOTIF AND METHODS OF USE THEREOF North Carolina State University (US) 2026-05-06 EP disclosed
EP-4705295-A2 MULTIFUNCTIONAL COMPOUND CORE FOR ACTIVE AGENTS AND USES THEREOF The University of North Carolina at Chapel Hill (US) 2026-03-11 EP disclosed
EP-4705400-A1 ADSORPTIVE COATINGS FOR METAL SURFACES AND RELATED METHODS Research Triangle Institute (US) 2026-03-11 EP disclosed
EP-0227932-B1 NOVEL FUSED PYRIDINE COMPOUNDS, INTERMEDIATES FOR THE PREPARATION OF, AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS AMERICAN CYANAMID COMPANY (US) 1993-01-13 EP disclosed
EP-0227932-A1 Novel fused pyridine compounds, intermediates for the preparation of, and use of said compounds as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1987-07-08 EP disclosed
CN-85103524-A Process for preparing 1, 5-benzothiazine derivatives 1986-11-05 CN disclosed
CN-85103524-A Process for preparing 1, 5-benzothiazine derivatives 1986-11-05 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020147192-A1 Chemokine receptor binding heterocyclic compounds CCR2, CXCR3, ACKR3 ALOX15 1853/4885ALDH1A1 1950/4885MAPK10 1517/4885
US-20070123510-A1 Guanidine derivatives NPFFR1, NPFFR2, OGFR ALOX15 3362/4885ALDH1A1 2183/4885MAPK10 925/4885
US-20080090846-A1 CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS CCR2, CXCR3, ACKR3 ALOX15 1853/4885ALDH1A1 1950/4885MAPK10 1517/4885
US-20050026942-A1 Chemokine receptor binding heterocyclic compounds CCR2, CXCR3, ACKR3 ALOX15 1853/4885ALDH1A1 1950/4885MAPK10 1517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.