Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.34 |
| ▸ | GOT1 | P17174 | 1/20 | 0.34 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.34 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13247401 | 1.00 | NOTUM (0.40) | NOTUMALDH1A1ERBB2AADATGOT1 | |
| SCHEMBL31011008 | 1.00 | NOTUM (0.40) | NOTUMALDH1A1ERBB2AADATGOT1 | |
| SCHEMBL22133029 | 0.84 | ERBB2 (0.39) | NOTUMALDH1A1ERBB2AADATKMT2A | |
| SCHEMBL25908151 | 0.84 | ERBB2 (0.39) | NOTUMALDH1A1ERBB2AADAT | |
| SCHEMBL13256748 | 0.84 | ERBB2 (0.39) | NOTUMALDH1A1ERBB2AADATGOT1 | |
| SCHEMBL25804321 | 0.84 | ERBB2 (0.42) | NOTUMALDH1A1ERBB2AADATGOT1 | |
| SCHEMBL22005902 | 0.84 | ERBB2 (0.42) | NOTUMALDH1A1ERBB2AADATGOT1 | |
| SCHEMBL14877746 | 0.83 | ERBB2 (0.41) | NOTUMALDH1A1ERBB2KMT2AKDM4E | |
| SCHEMBL19339961 | 0.81 | ERBB2 (0.42) | ALDH1A1ERBB2AADATKYAT1KYAT3 | |
| SCHEMBL17915864 | 0.81 | ERBB2 (0.41) | NOTUMALDH1A1ERBB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442809-B2 | Methods for preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-ones | IMMUNOGEN, INC. (US) | 2019-10-15 | — | — | US | disclosed |
| US-9987374-B2 | Cyclodextrin and antibody-drug conjugate formulations | SEATTLE GENETICS, INC. (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170232112-A1 | CYCLODEXTRIN AND ANTIBODY-DRUG CONJUGATE FORMULATIONS | SEATTLE GENETICS, INC. (US) | 2017-08-17 | — | — | US | disclosed |
| US-20170232112-A1 | CYCLODEXTRIN AND ANTIBODY-DRUG CONJUGATE FORMULATIONS | SEATTLE GENETICS, INC. (US) | 2017-08-17 | — | — | US | disclosed |
| US-9610361-B2 | Cyclodextrin and antibody-drug conjugate formulations | SEATTLE GENETICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-9610361-B2 | Cyclodextrin and antibody-drug conjugate formulations | SEATTLE GENETICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-9453046-B2 | Activated carbon filtration for purification of benzodiazepine ADCs | SEATTLE GENETICS, INC. (US) | 2016-09-27 | — | — | US | disclosed |
| US-9453046-B2 | Activated carbon filtration for purification of benzodiazepine ADCs | SEATTLE GENETICS, INC. (US) | 2016-09-27 | — | — | US | disclosed |
| US-20160039870-A1 | ACTIVATED CARBON FILTRATION FOR PURIFICATION OF BENZODIAZEPINE ADCS | SEATTLE GENETICS, INC. (US) | 2016-02-11 | — | — | US | disclosed |
| US-20160039870-A1 | ACTIVATED CARBON FILTRATION FOR PURIFICATION OF BENZODIAZEPINE ADCS | SEATTLE GENETICS, INC. (US) | 2016-02-11 | — | — | US | disclosed |
| WO-2014165119-A1 | CYCLODEXTRIN AND ANTIBODY-DRUG CONJUGATE FORMULATIONS | SEATTLE GENETICS, INC. (US) | 2014-10-09 | — | — | WO | disclosed |
| WO-2014143622-A1 | ACTIVATED CARBON FILTRATION FOR PURIFICATION OF BENZODIAZEPINE ADCs | SEATTLE GENETICS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039870-A1 | ACTIVATED CARBON FILTRATION FOR PURIFICATION OF BENZODIAZEPINE ADCS | GABRA4, GABRA3, GABRA2 | NOTUM 3029/4885ALDH1A1 654/4885ERBB2 495/4885 |
| US-10442809-B2 | Methods for preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-ones | HTR6, HTR3D, HTR3C | NOTUM 3541/4885ALDH1A1 340/4885ERBB2 1053/4885 |
| US-20170232112-A1 | CYCLODEXTRIN AND ANTIBODY-DRUG CONJUGATE FORMULATIONS | CDR2, GABRA6, GABRA4 | NOTUM 2535/4885ALDH1A1 610/4885ERBB2 839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.