Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hippuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.51 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.49 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.49 |
| ▸ | PTPRC | P08575 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hippuric Acid SCHEMBL1609915 | 0.92 | NPC1 (0.49) | LMNAMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22030672 | 0.84 | GAA (0.68) | LMNANPC1RAB9ASMN1; SMN2GPR139 | |
| Hippuric Acid SCHEMBL7486 | 0.84 | GAA (0.68) | LMNANPC1RAB9ASMN1; SMN2GPR139 | |
| Hippuric Acid SCHEMBL428479 | 0.84 | GAA (0.68) | LMNANPC1RAB9ASMN1; SMN2GPR139 | |
| Hippuric Acid SCHEMBL9135405 | 0.83 | GPR139 (0.56) | LMNANPC1RAB9ASMN1; SMN2GPR139 | |
| Hippuric Acid SCHEMBL3448563 | 0.82 | MAPT (0.66) | LMNANPC1RAB9ASMN1; SMN2GPR139 | |
| Hippuric Acid SCHEMBL1458080 | 0.82 | MAPT (0.66) | LMNANPC1RAB9ASMN1; SMN2GPR139 | |
| Hippuric Acid SCHEMBL7796688 | 0.82 | KDM4E (0.66) | LMNANPC1RAB9ASMN1; SMN2GPR139 | |
| Hippuric Acid SCHEMBL21569381 | 0.82 | MAPT (0.66) | LMNANPC1RAB9ASMN1; SMN2GPR139 | |
| Hippuric Acid SCHEMBL587978 | 0.82 | MAPT (0.66) | LMNANPC1RAB9ASMN1; SMN2GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119343143-A | Boron-containing pyrimidine compounds, compositions containing them, methods and uses thereof | 博拉公司 | 2025-01-21 | — | — | CN | disclosed |