Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1610287 | 0.93 | KMT2A (0.52) | KMT2AMEN1MAOBHTTPDK1 | |
| SCHEMBL1647802 | 0.84 | MAPK1 (0.64) | KMT2AMEN1MAPK1CES2CES1 | |
| SCHEMBL1609756 | 0.84 | MAPK1 (0.64) | KMT2AMEN1MAPK1CES2CES1 | |
| SCHEMBL18013199 | 0.82 | VCAM1 (0.61) | KMT2AMEN1HTTALDH1A1VCAM1 | |
| SCHEMBL28403587 | 0.81 | LMNA (0.47) | KMT2AMEN1MAPK1CES2CES1 | |
| SCHEMBL1609806 | 0.81 | CASP6 (0.66) | KMT2ATSHRCASP6LMNA | |
| SCHEMBL10623585 | 0.80 | CES2 (0.71) | KMT2AMEN1MAPK1CES2CES1 | |
| Hydrochloric Acid SCHEMBL1609389 | 0.79 | CASP6 (0.64) | KMT2ATSHRCASP6LMNA | |
| Ethyl Acetate SCHEMBL27685578 | 0.78 | MAPK1 (0.53) | KMT2AMEN1MAPK1CES2CES1 | |
| SCHEMBL12775960 | 0.77 | KMT2A (0.60) | KMT2AMEN1MAPK1MAOBPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311792-B1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | ROCHE DIAGNOSTICS GMBH (DE) | 2013-05-15 | — | — | EP | claimed |
| US-20110087013-A1 | Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones | ROCHE NIMBLEGEN, INC. | 2011-04-14 | — | — | US | claimed |
| EP-2311792-A1 | Friedel-Crafts acylation for synthesis of aryl and heteroaryl-(3-ethyl-4-nitro-phenyl)-methanones | Roche Diagnostics GmbH (DE) | 2011-04-20 | — | — | EP | disclosed |
| US-20110087013-A1 | Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones | ROCHE NIMBLEGEN, INC. | 2011-04-14 | — | — | US | disclosed |
| US-20110087013-A1 | Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones | ROCHE NIMBLEGEN, INC. | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110087013-A1 | Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones | CYP2B6, HNF4A, AHR | KMT2A 921/4885MEN1 3705/4885MAPK1 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.