Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 4/20 | 0.63 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.63 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.63 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.63 |
| ▸ | LDHA | P00338 | 1/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.63 |
| ▸ | FBP1 | P09467 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.63 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.63 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.63 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.63 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16130074 | 0.91 | P2RX3 (0.64) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| SCHEMBL17481937 | 0.90 | P2RY1 (0.52) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL16094147 | 0.90 | P2RX3 (0.63) | P2RY1P2RY2SRCSMN1; SMN2TRPM2 | |
| SCHEMBL19326673 | 0.85 | P2RY1 (0.53) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL16094141 | 0.85 | P2RY1 (0.53) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL19337228 | 0.84 | P2RY1 (0.49) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL20019755 | 0.83 | DNPH1 (0.61) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL8860422 | 0.81 | AHCY (0.49) | SMN1; SMN2ADORA1 | |
| SCHEMBL1052757 | 0.81 | AHCY (0.60) | SMN1; SMN2ADORA1 | |
| SCHEMBL8712829 | 0.81 | AHCY (0.60) | SMN1; SMN2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RANA THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RANA THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20210009629-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2021-01-14 | — | — | US | disclosed |
| US-10822368-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | TRANSLATE BIO, INC. (US) | 2020-11-03 | — | — | US | disclosed |
| US-20190263850-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2019-08-29 | — | — | US | disclosed |
| US-10266559-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | TRANSLATE BIO, INC. (US) | 2019-04-23 | — | — | US | disclosed |
| EP-2970351-B1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO INC (US) | 2017-09-13 | — | — | EP | disclosed |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2016-02-04 | — | — | US | disclosed |
| WO-2014152513-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822368-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | RNMT, RNGTT, NSUN3 | P2RY1 1529/4885P2RY2 1817/4885SRC 3722/4885 |
| US-20190263850-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | P2RY1 1511/4885P2RY2 1784/4885SRC 3764/4885 |
| US-20210009629-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | P2RY1 1511/4885P2RY2 1784/4885SRC 3764/4885 |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | P2RY1 1511/4885P2RY2 1784/4885SRC 3764/4885 |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | P2RY1 1511/4885P2RY2 1784/4885SRC 3764/4885 |
| US-10266559-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | RNMT, RNGTT, NSUN3 | P2RY1 1529/4885P2RY2 1817/4885SRC 3722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.