Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 5/20 | 0.64 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.64 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.64 |
| ▸ | P2RY1 | P47900 | 8/20 | 0.61 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.61 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.59 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.58 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.58 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.58 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.58 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16094147 | 0.99 | P2RX3 (0.63) | P2RX3P2RX1P2RX2P2RY1P2RY2 | |
| SCHEMBL16130072 | 0.91 | P2RY1 (0.63) | P2RX3P2RX1P2RX2P2RY1P2RY2 | |
| SCHEMBL17481937 | 0.86 | P2RY1 (0.52) | P2RX3P2RX1P2RX2P2RY1P2RY2 | |
| SCHEMBL6035384 | 0.85 | P2RX1 (0.62) | P2RX3P2RX1P2RX2P2RY1P2RY2 | |
| SCHEMBL6035368 | 0.85 | P2RX1 (0.62) | P2RX3P2RX1P2RX2P2RY1P2RY2 | |
| SCHEMBL19337228 | 0.83 | P2RY1 (0.49) | P2RX3P2RX1P2RX2P2RY1P2RY2 | |
| SCHEMBL19326673 | 0.83 | P2RY1 (0.53) | P2RX3P2RX1P2RX2P2RY1P2RY2 | |
| SCHEMBL16094141 | 0.83 | P2RY1 (0.53) | P2RX3P2RX1P2RX2P2RY1P2RY2 | |
| SCHEMBL6036072 | 0.81 | TGM2 (0.57) | P2RX3P2RY2 | |
| SCHEMBL6036078 | 0.81 | TGM2 (0.57) | P2RX3P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RANA THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20210009629-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2021-01-14 | — | — | US | disclosed |
| US-10822368-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | TRANSLATE BIO, INC. (US) | 2020-11-03 | — | — | US | disclosed |
| US-20190263850-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2019-08-29 | — | — | US | disclosed |
| US-10266559-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | TRANSLATE BIO, INC. (US) | 2019-04-23 | — | — | US | disclosed |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | TRANSLATE BIO, INC. | 2016-02-04 | — | — | US | disclosed |
| WO-2014152513-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822368-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | RNMT, RNGTT, NSUN3 | P2RX3 1600/4885P2RX1 1582/4885P2RX2 1837/4885 |
| US-20190263850-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | P2RX3 1590/4885P2RX1 1575/4885P2RX2 1811/4885 |
| US-20210009629-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | P2RX3 1590/4885P2RX1 1575/4885P2RX2 1811/4885 |
| US-20230192753-A1 | RIBONUCLEIC ACIDS WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | P2RX3 1590/4885P2RX1 1575/4885P2RX2 1811/4885 |
| US-20160031928-A1 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS | RNMT, RNGTT, NSUN3 | P2RX3 1590/4885P2RX1 1575/4885P2RX2 1811/4885 |
| US-10266559-B2 | Ribonucleic acids with 4′-thio-modified nucleotides and related methods | RNMT, RNGTT, NSUN3 | P2RX3 1600/4885P2RX1 1582/4885P2RX2 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.