Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16136770 | 0.88 | PDE4D (0.42) | PDE4DSMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL908743 | 0.71 | SLC18A3 (0.53) | PDE4DSMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL1616382 | 0.68 | PDE4D (0.38) | PDE4DSMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL1616383 | 0.68 | PDE4D (0.38) | PDE4DSMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL9537080 | 0.67 | L3MBTL3 (0.35) | PDE4DSMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL10697281 | 0.67 | L3MBTL3 (0.35) | PDE4DSMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL131067 | 0.65 | SMN1; SMN2 (0.44) | PDE4DSMN1; SMN2ALDH1A1HSD17B10MEN1 | |
| SCHEMBL18660279 | 0.64 | ALDH1A1 (0.62) | PDE4DSMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL11340788 | 0.63 | ALDH1A1 (0.61) | PDE4DSMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL15324048 | 0.63 | SMN1; SMN2 (0.35) | SMN1; SMN2L3MBTL1L3MBTL3CYP2A13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853281-B2 | Cysteine protease inhibitors | MEDIVIR UK LTD (GB) | 2014-10-07 | — | — | US | disclosed |
| US-20110312964-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR UK LTD (GB) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312964-A1 | CYSTEINE PROTEASE INHIBITORS | CTSS, CTSB, CTSV | PDE4D 3385/4885SMN1; SMN2 4777/4885TSHR 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.