Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.63 |
| ▸ | PRKCG | P05129 | 5/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.63 |
| ▸ | PRKCB | P05771 | 4/20 | 0.63 |
| ▸ | PRKCH | P24723 | 4/20 | 0.63 |
| ▸ | PRKCI | P41743 | 4/20 | 0.63 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.63 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.63 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.63 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.63 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82376 | 0.91 | PRKCA (0.63) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| SCHEMBL1258697 | 0.91 | PRKCA (0.62) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| Phorbol SCHEMBL28498206 | 0.88 | PRKCA (0.51) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| SCHEMBL18399979 | 0.88 | PRKCA (0.79) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| SCHEMBL18622646 | 0.88 | PRKCA (0.79) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| SCHEMBL15725680 | 0.88 | PRKCA (0.79) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| SCHEMBL3516162 | 0.88 | PRKCA (0.79) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| SCHEMBL31074956 | 0.88 | PRKCA (0.79) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| SCHEMBL258513 | 0.88 | PRKCA (0.79) | PRKCAPRKCGPRKD3PRKCBPRKCH | |
| SCHEMBL18629158 | 0.88 | PRKCA (0.79) | PRKCAPRKCGPRKD3PRKCBPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040213782-A1 | Compositions of an aquaporin modulating agent and an aqueous humor modulating agent for the treatment of elevated intraocular pressure | PHARMACIA CORPORATION | 2004-10-28 | — | — | US | claimed |
| WO-2004069181-A2 | COMPOSITION FOR THE TREATMENT OF INTRAOCULAR PRESSURE | PHARMACIA CORPORATION (US) | 2004-08-19 | — | — | WO | claimed |
| WO-2011044548-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | US | disclosed |
| US-20040213782-A1 | Compositions of an aquaporin modulating agent and an aqueous humor modulating agent for the treatment of elevated intraocular pressure | PHARMACIA CORPORATION | 2004-10-28 | — | — | US | disclosed |
| WO-2004069181-A2 | COMPOSITION FOR THE TREATMENT OF INTRAOCULAR PRESSURE | PHARMACIA CORPORATION (US) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086895-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | PCK2, AK2, SIRT6 | PRKCA 275/4885PRKCG 493/4885PRKD3 187/4885 |
| US-20040213782-A1 | Compositions of an aquaporin modulating agent and an aqueous humor modulating agent for the treatment of elevated intraocular pressure | AQP1, AQP4, AQP3 | PRKCA 433/4885PRKCG 332/4885PRKD3 1314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.