SCHEMBL16167739

SCHEMBL16167739

COc1cc(C)cc(C=Cc2ccc(N(c3ccc(C=Cc4cc(C)cc(OC)c4)cc3)c3ccc(C=Cc4cc(OC)cc(OC)c4)cc3)cc2)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 7/20 0.61
CYP1B1 Q16678 7/20 0.61
NQO2 P16083 5/20 0.61
ESR1 P03372 4/20 0.61
TTR P02766 4/20 0.61
PTGS2 P35354 4/20 0.61
AHR P35869 3/20 0.61
ALOX5 P09917 3/20 0.61
CYP1A2 P05177 3/20 0.61
ABL1 P00519 2/20 0.61
ABCB1 P08183 2/20 0.61
BCR P11274 2/20 0.61
CYP19A1 P11511 2/20 0.61
TUBB4A P04350 2/20 0.61
TUBB P07437 2/20 0.61
TUBA3C P0DPH7 2/20 0.61
TUBA1B P68363 2/20 0.61
TUBA4A P68366 2/20 0.61
TUBB4B P68371 2/20 0.61
TUBB3 Q13509 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8206188 0.92 CYP1A1 (0.62) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL8206185 0.92 CYP1A1 (0.62) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL16168068 0.92 CYP1A1 (0.71) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL10015728 0.87 CYP1A1 (0.55) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL10312395 0.84 RELA (0.68) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL12535856 0.84 PTGS2 (0.78) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL16362233 0.84 CYP1A1 (0.77) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL14570385 0.83 TRPA1 (0.57) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL8199126 0.83 PTGS2 (0.67) CYP1A1CYP1B1NQO2ESR1TTR
SCHEMBL8199129 0.83 PTGS2 (0.67) CYP1A1CYP1B1NQO2ESR1TTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8859818-B2 Electrophotographic photoreceptor TAKASAGO INTERNATIONAL CORPORATION (JP) 2014-10-14 US disclosed