Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28767631 | 0.77 | P2RX3 (0.31) | — | |
| SCHEMBL29211469 | 0.73 | — | — | |
| SCHEMBL28952056 | 0.73 | ALDH1A1 (0.41) | — | |
| SCHEMBL29011021 | 0.73 | — | — | |
| SCHEMBL28952050 | 0.69 | MEN1 (0.40) | — | |
| SCHEMBL31337149 | 0.67 | NPC1 (0.32) | — | |
| SCHEMBL29211484 | 0.66 | HRH4 (0.40) | — | |
| SCHEMBL7398610 | 0.66 | NPC1 (0.35) | PTGS2 | |
| SCHEMBL9256983 | 0.65 | GAA (0.35) | — | |
| SCHEMBL998696 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240139327-A1 | PRODRUG COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | MINGHUI PHARMACEUTICAL (HANGZHOU) LIMITED (CN) | 2024-05-02 | — | — | US | disclosed |
| CN-113631557-B | JAK kinase inhibitor, preparation method thereof and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-111936144-B | JAK inhibitors | 廖细斌 | 2023-12-22 | — | — | CN | disclosed |
| EP-4293020-A1 | PRODRUG COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Minghui Pharmaceutical (Hangzhou) Limited (CN) | 2023-12-20 | — | — | EP | disclosed |
| CN-116848104-A | Prodrug compound and preparation method and application thereof | 明慧医药（杭州）有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-111320633-B | Pyrrole/imidazo six-membered heteroaromatic ring compound and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2022-09-27 | — | — | CN | disclosed |
| CN-114591321-A | Aza-and-cyclic compounds, method for the production thereof and use thereof | 广州费米子科技有限责任公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-113631557-A | JAK kinase inhibitor, preparation method thereof and application thereof in medical field | 上海华汇拓医药科技有限公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-111936144-A | JAK inhibitors | 廖细斌 | 2020-11-13 | — | — | CN | disclosed |
| WO-2020182159-A1 | JAK KINASE INHIBITOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF IN FIELD OF MEDICINE | 上海华汇拓医药科技有限公司 | 2020-09-17 | — | — | WO | disclosed |
| CN-111320633-A | Pyrrole/imidazo six-membered heteroaromatic ring compound and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2020-06-23 | — | — | CN | disclosed |
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-10-01 | — | — | US | disclosed |
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| EP-2796460-B1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2018-07-04 | — | — | EP | disclosed |
| EP-3006445-B1 | BISULFATE OF JANUS KINASE (JAK) INHIBITOR AND PREPARATION METHOD THEREFOR | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-11-15 | — | — | EP | disclosed |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-02-16 | — | — | US | disclosed |
| EP-3006445-A1 | BISULFATE OF JANUS KINASE (JAK) INHIBITOR AND PREPARATION METHOD THEREFOR | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2016-04-13 | — | — | EP | disclosed |
| EP-2796460-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | DHFR, PPOX, PAH | CHRM2 4665/4885CHRM4 4760/4885CHRM5 4548/4885 |
| US-20240139327-A1 | PRODRUG COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | CYP51A1, CYP4F11, NOTUM | CHRM2 4491/4885CHRM4 4377/4885CHRM5 4381/4885 |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JAK2, JAK1, JAK3 | CHRM2 4852/4885CHRM4 4878/4885CHRM5 4854/4885 |
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | DHFR, PPOX, PAH | CHRM2 4665/4885CHRM4 4760/4885CHRM5 4548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.