Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.33 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20343397 | 1.00 | JAK2 (0.39) | JAK2JAK1HSD11B1DPP4CHRNB2 | |
| SCHEMBL20343430 | 0.85 | JAK1 (0.46) | JAK2JAK1HSD11B1DPP4CHRNB2 | |
| SCHEMBL20343418 | 0.81 | HSD11B1 (0.41) | JAK2JAK1HSD11B1DPP4CHRNB2 | |
| SCHEMBL15077584 | 0.78 | HSD11B1 (0.46) | JAK2JAK1HSD11B1DPP4CHRNB2 | |
| SCHEMBL20343504 | 0.77 | HSD11B1 (0.44) | HSD11B1DPP4CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL20343448 | 0.76 | CHRNB2 (0.56) | HSD11B1CHRNB2CHRNA3CHRNA4CHRNB4 | |
| SCHEMBL22436128 | 0.75 | ATM (0.58) | MAPTMEN1KMT2AATMNPC1 | |
| SCHEMBL20343499 | 0.72 | HSD11B1 (0.47) | JAK2JAK1HSD11B1DPP4CHRNB2 | |
| SCHEMBL20343378 | 0.72 | HSD11B1 (0.47) | JAK2JAK1HSD11B1DPP4CHRNB2 | |
| SCHEMBL4436959 | 0.71 | ALDH1A1 (0.52) | JAK2HSD11B1CHRNB2CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-10-01 | — | — | US | disclosed |
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| EP-2796460-B1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2018-07-04 | — | — | EP | disclosed |
| EP-2796460-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | DHFR, PPOX, PAH | JAK2 243/4885JAK1 1695/4885HSD11B1 401/4885 |
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | DHFR, PPOX, PAH | JAK2 243/4885JAK1 1695/4885HSD11B1 401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.