SCHEMBL16202000

SCHEMBL16202000

Cc1ncn(-c2ccc(C(F)(F)F)cc2Cl)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSEN1 P49768 1/20 0.41
PSEN2 P49810 1/20 0.41
APH1B Q8WW43 1/20 0.41
NCSTN Q92542 1/20 0.41
APH1A Q96BI3 1/20 0.41
PSENEN Q9NZ42 1/20 0.41
MALT1 Q9UDY8 2/20 0.41
GPR119 Q8TDV5 2/20 0.39
PDE2A O00408 1/20 0.39
PHGDH O43175 1/20 0.38
ALDH1A1 P00352 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
GAA P10253 3/20 0.37
ATM Q13315 1/20 0.37
HCRTR1 O43613 1/20 0.36
HSD11B1 P28845 1/20 0.36
TP53 P04637 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16202002 0.88 CRHBP (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL17720567 0.80 POLB (0.41) MALT1NPC1RAB9AHCRTR1TP53
SCHEMBL16201998 0.80 KCNH2 (0.43) ALDH1A1GAAHSD11B1
SCHEMBL30725597 0.80 KCNH2 (0.43) ALDH1A1GAAHSD11B1
SCHEMBL19814290 0.77 MAPT (0.44) MALT1ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL21030429 0.75 MALT1 (0.34) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL16202025 0.74 KCNH2 (0.42) ATM
SCHEMBL2913915 0.73 POLB (0.38) MALT1ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL16335028 0.73 ALDH1A1 (0.60) GPR119PHGDHALDH1A1SMN1; SMN2RAB9A
SCHEMBL28853709 0.73 NOTUM (0.60) GPR119PDE2AALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9271501-B2 Use of strobilurin type compounds for combating phytopathogenic fungi resistant to QO inhibitors BASF SE (DE) 2016-03-01 US disclosed
US-20140323305-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors BASF SE (DE) 2014-10-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140323305-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors SQOR, COX5B, UQCRB PSEN1 1460/4885PSEN2 1821/4885APH1B 1218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.