SCHEMBL16202024

SCHEMBL16202024

Cc1ncn(-c2ccc(F)cc2)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 6/20 0.42
NOTUM Q6P988 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
TP53 P04637 1/20 0.41
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
LMNA P02545 2/20 0.38
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
KDM4E B2RXH2 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
JUN P05412 1/20 0.36
PCSK9 Q8NBP7 1/20 0.36
FLT3 P36888 1/20 0.36
ACHE P22303 1/20 0.36
PSEN1 P49768 1/20 0.35
PSEN2 P49810 1/20 0.35
APH1B Q8WW43 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13183810 0.83 ALDH1A1 (0.45) MAPK10NOTUMSMN1; SMN2TP53LMNA
SCHEMBL16202009 0.80 NOTUM (0.46) MAPK10NOTUMNPC1RAB9AKMT2A
SCHEMBL20260648 0.80 KAT7 (0.35) MAPK10JUNPSEN1PSEN2APH1B
SCHEMBL719104 0.80 MAPT (0.46) MAPK10LMNAJUNPCSK9ACHE
SCHEMBL4873943 0.80 MAPK10 (0.42) MAPK10LMNAKMT2AMEN1HPGD
SCHEMBL15299233 0.80 MAPK10 (0.42) MAPK10NPC1RAB9ALMNAKMT2A
SCHEMBL719952 0.80 MAPK10 (0.42) MAPK10SMN1; SMN2TP53NPC1RAB9A
SCHEMBL16202025 0.79 KCNH2 (0.42) MAPK10NOTUM
SCHEMBL7044640 0.79 HPGD (0.49) MAPK10NOTUMSMN1; SMN2TP53NPC1
Hydrochloric Acid SCHEMBL5799102 0.78 MAPK10 (0.41) MAPK10SMN1; SMN2TP53NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160249615-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors BASF SE (DE) 2016-09-01 US disclosed
US-20160145219-A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2016-05-26 US disclosed
US-20160145202-A1 Strobilurin Type Compounds for Combating Phytopathogenic Fungi BASF SE (DE) 2016-05-26 US disclosed
US-20160122327-A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI BASF SE (DE) 2016-05-05 US disclosed
US-9271501-B2 Use of strobilurin type compounds for combating phytopathogenic fungi resistant to QO inhibitors BASF SE (DE) 2016-03-01 US disclosed
US-20140323305-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors BASF SE (DE) 2014-10-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160122327-A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI SNX1, DPM1, SNU13 MAPK10 4384/4885NOTUM 2417/4885SMN1; SMN2 2653/4885
US-20160145219-A1 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI DPM1, CROCC, SNX1 MAPK10 4393/4885NOTUM 2527/4885SMN1; SMN2 3486/4885
US-20160145202-A1 Strobilurin Type Compounds for Combating Phytopathogenic Fungi DPM1, CROCC, SNX1 MAPK10 4393/4885NOTUM 2527/4885SMN1; SMN2 3486/4885
US-20140323305-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors SQOR, COX5B, UQCRB MAPK10 4416/4885NOTUM 3419/4885SMN1; SMN2 2724/4885
US-20160249615-A1 Use of Strobilurin Type Compounds for Combating Phytopathogenic Fungi Resistant to QO Inhibitors SQOR, COX5B, UQCRB MAPK10 4416/4885NOTUM 3419/4885SMN1; SMN2 2724/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.