Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 17/20 | 0.78 |
| ▸ | IKBKE | Q14164 | 8/20 | 0.78 |
| ▸ | NPC1 | O15118 | 4/20 | 0.78 |
| ▸ | RAB9A | P51151 | 4/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.78 |
| ▸ | TTR | P02766 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | PKM | P14618 | 1/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.78 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.78 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.78 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.78 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17548698 | 0.89 | TBK1 (0.74) | TBK1IKBKENPC1RAB9AKDM4E | |
| Amlexanox SCHEMBL29642 | 0.88 | TBK1 (1.00) | TBK1IKBKENPC1RAB9AKDM4E | |
| Amlexanox SCHEMBL5058549 | 0.88 | TBK1 (1.00) | TBK1IKBKENPC1RAB9AKDM4E | |
| Amlexanox SCHEMBL29441547 | 0.88 | TBK1 (1.00) | TBK1IKBKENPC1RAB9AKDM4E | |
| Amlexanox SCHEMBL29381739 | 0.88 | TBK1 (1.00) | TBK1IKBKENPC1RAB9AKDM4E | |
| SCHEMBL19199806 | 0.87 | TBK1 (1.00) | TBK1IKBKENPC1RAB9AKDM4E | |
| Amlexanox SCHEMBL2902814 | 0.87 | TBK1 (0.98) | TBK1IKBKENPC1RAB9AKDM4E | |
| SCHEMBL19197522 | 0.87 | TBK1 (0.81) | TBK1IKBKENPC1RAB9AKDM4E | |
| Amlexanox SCHEMBL2908304 | 0.87 | TBK1 (0.98) | TBK1IKBKENPC1RAB9AKDM4E | |
| Amlexanox SCHEMBL2907023 | 0.87 | TBK1 (0.98) | TBK1IKBKENPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590142-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-03-17 | — | — | US | disclosed |
| EP-2991647-B1 | DEUTERATED AMLEXANOX WITH IMPROVED METABOLIC STABILITY | UNIV MICHIGAN REGENTS (US) | 2019-04-24 | — | — | EP | disclosed |
| US-9944652-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-04-17 | — | — | US | disclosed |
| US-20160251366-A1 | DEUTERATED AMLEXANOX | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2016-09-01 | — | — | US | disclosed |
| US-9365581-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-06-14 | — | — | US | disclosed |
| US-20160060271-A1 | DEUTERATED AMLEXANOX | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-03-03 | — | — | US | disclosed |
| US-8946424-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-02-03 | — | — | US | disclosed |
| US-20140329848-A1 | DEUTERATED AMLEXANOX | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590142-B2 | Deuterated amlexanox | DDX3X, DHX30, HAX1 | TBK1 3563/4885IKBKE 3768/4885NPC1 2073/4885 |
| US-20140329848-A1 | DEUTERATED AMLEXANOX | DDX3X, DHX30, HAX1 | TBK1 3563/4885IKBKE 3768/4885NPC1 2073/4885 |
| US-20160060271-A1 | DEUTERATED AMLEXANOX | AADAC, GPR119, IAPP | TBK1 1397/4885IKBKE 1010/4885NPC1 2109/4885 |
| US-20160251366-A1 | DEUTERATED AMLEXANOX | DDX3X, DHX30, HAX1 | TBK1 3563/4885IKBKE 3768/4885NPC1 2073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.