Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | ACACA | Q13085 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31225434 | 0.84 | KDM4E (0.56) | KDM4ERAB9ANPC1GAAACACB | |
| SCHEMBL15054860 | 0.84 | KDM4E (0.56) | KDM4ERAB9ANPC1GAAACACB | |
| SCHEMBL9889562 | 0.83 | TAAR1 (0.52) | KDM4ERAB9ANPC1GAAMEN1 | |
| SCHEMBL9889505 | 0.83 | KDM4E (0.51) | KDM4ERAB9ANPC1GAAACACB | |
| SCHEMBL12341170 | 0.80 | IGF1R (0.47) | POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8737052 | 0.80 | KDM4E (0.66) | KDM4ERAB9ANPC1GAAMEN1 | |
| SCHEMBL5943019 | 0.79 | RAB9A (0.44) | KDM4ERAB9ANPC1GAAACACB | |
| SCHEMBL21656822 | 0.79 | GRM2 (0.57) | KDM4EMEN1KMT2ANFKB1OPRM1 | |
| SCHEMBL21656688 | 0.79 | PDE4B (0.53) | ACACBOPRM1OPRD1OPRK1MAPT | |
| SCHEMBL21628606 | 0.78 | OPRM1 (0.67) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030855-B2 | Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts | CELLESTIA BIOTECH AG (CH) | 2024-07-09 | — | — | US | disclosed |
| US-20180224429-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2018-08-09 | — | — | US | disclosed |
| US-9296682-B2 | Inhibitors of notch signalling pathway and use thereof in treatment of cancers | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) | 2016-03-29 | — | — | US | disclosed |
| US-20140329867-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2014-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329867-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | NOTCH3, NOTCH1, NOTCH4 | KDM4E 464/4885RAB9A 3103/4885NPC1 2594/4885 |
| US-12030855-B2 | Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts | ADH1C, ADH1A, DDC | KDM4E 499/4885RAB9A 932/4885NPC1 3749/4885 |
| US-20180224429-A1 | INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS | NOTCH3, NOTCH1, NOTCH4 | KDM4E 464/4885RAB9A 3103/4885NPC1 2594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.