Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC8A1 | P32418 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PCK1 | P35558 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229792 | 0.93 | POLB (0.35) | SLC8A1SMN1; SMN2POLBMETHTR1A | |
| SCHEMBL16229798 | 0.92 | HTR6 (0.36) | SLC8A1LIPCHTR1AHTR7LMNA | |
| SCHEMBL16229766 | 0.91 | TP53 (0.35) | SLC8A1SMN1; SMN2METSLC6A9GNRHR | |
| SCHEMBL16229772 | 0.90 | AXL (0.37) | SLC8A1SMN1; SMN2LMNASLC6A9 | |
| SCHEMBL16784645 | 0.86 | SLC6A9 (0.41) | SLC8A1SMN1; SMN2METHTR1AHTR7 | |
| SCHEMBL16784640 | 0.86 | SLC6A9 (0.41) | SLC8A1SMN1; SMN2POLBHTR1AHTR7 | |
| SCHEMBL16229806 | 0.85 | DGAT1 (0.35) | POLBMETLMNAKMT2ASLC6A9 | |
| SCHEMBL16229758 | 0.85 | LMNA (0.50) | SLC8A1POLBLMNAKMT2ASLC6A9 | |
| SCHEMBL16229761 | 0.84 | SLC6A9 (0.37) | LMNAKMT2ASLC6A9 | |
| SCHEMBL16229800 | 0.83 | SLC6A9 (0.36) | HTR1AHTR7SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |