Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229806 | 0.93 | DGAT1 (0.35) | HTR6SLC6A9AKR1C3ALDH1A1LMNA | |
| SCHEMBL16784652 | 0.92 | SLC8A1 (0.37) | SLC6A9SLC8A1LMNAKDM4ELIPC | |
| SCHEMBL16229761 | 0.92 | SLC6A9 (0.37) | HTR6SLC6A9AKR1C3ALDH1A1LMNA | |
| SCHEMBL16229800 | 0.90 | SLC6A9 (0.36) | HTR6SLC6A9HTR1AHTR7 | |
| SCHEMBL16784640 | 0.88 | SLC6A9 (0.41) | HTR6SLC6A9SLC8A1ALDH1A1HTR1A | |
| SCHEMBL16229746 | 0.87 | HTT (0.40) | SLC6A9PKMSLC8A1ALDH1A1LMNA | |
| SCHEMBL16229792 | 0.85 | POLB (0.35) | SLC6A9PKMSLC8A1ALDH1A1KDM4E | |
| SCHEMBL16229748 | 0.85 | SLC6A9 (0.45) | SLC6A9LMNAGAA | |
| SCHEMBL16229766 | 0.84 | TP53 (0.35) | SLC6A9PKMSLC8A1MAPK1 | |
| SCHEMBL16229772 | 0.82 | AXL (0.37) | SLC6A9SLC8A1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |