Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | BUB1 | O43683 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714826 | 0.88 | LMNA (0.48) | LMNACYP2C19CYP3A4CYP2C9PTPN1 | |
| SCHEMBL16370023 | 0.82 | CYP3A4 (0.45) | LMNACYP2C19CYP3A4CYP2C9PTPN1 | |
| SCHEMBL4869082 | 0.78 | CTSL (0.47) | LMNACYP2C19CYP3A4CYP2C9BUB1 | |
| SCHEMBL4869078 | 0.78 | CTSL (0.47) | LMNACYP2C19CYP3A4CYP2C9BUB1 | |
| SCHEMBL17391117 | 0.76 | TSHR (0.48) | LMNATSHRCTSLCTSBCTSK | |
| SCHEMBL21609457 | 0.76 | TSHR (0.48) | LMNATSHRCTSLCTSBCTSK | |
| SCHEMBL21609456 | 0.76 | TSHR (0.48) | LMNATSHRCTSLCTSBCTSK | |
| SCHEMBL21610692 | 0.76 | TSHR (0.48) | LMNATSHRCTSLCTSBCTSK | |
| SCHEMBL13942030 | 0.76 | TSHR (0.48) | LMNATSHRCTSLCTSBCTSK | |
| SCHEMBL421810 | 0.74 | CTSL (0.49) | LMNABUB1TSHRCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928091-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA LTD. (CA) | 2011-04-19 | — | — | US | disclosed |
| US-20090093444-A1 | Cathepsin Cysteine Protease Inhibitors | MERCK FROSST CANADA LTD. (CA) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093444-A1 | Cathepsin Cysteine Protease Inhibitors | CTSB, CTSS, CTSZ | LMNA 2431/4885CYP2C19 3731/4885CYP3A4 4149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.