SCHEMBL16233181

SCHEMBL16233181

Cc1cc(C(=O)NCC2(N3CCOCC3)CCOCC2)cc(C)c1OCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.49
HCN4 Q9Y3Q4 2/20 0.48
THRB P10828 3/20 0.48
LMNA P02545 2/20 0.48
SLC6A5 Q9Y345 3/20 0.47
HCN1 O60741 1/20 0.47
ALDH1A1 P00352 2/20 0.46
TSHR P16473 1/20 0.45
MAPT P10636 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16233193 0.94 HCN1 (0.53) HCN4LMNASLC6A5HCN1
SCHEMBL16233235 0.89 SLC6A5 (0.62) TDP1HCN4THRBLMNASLC6A5
SCHEMBL16233199 0.84 LMNA (0.56) HCN4THRBLMNAALDH1A1MAPT
SCHEMBL16233224 0.84 HCN1 (0.61) HCN4THRBLMNASLC6A5HCN1
SCHEMBL16234622 0.83 SLC6A5 (0.58) TDP1THRBLMNASLC6A5ALDH1A1
SCHEMBL16233170 0.83 SLC6A5 (0.61) HCN4SLC6A5HCN1ALDH1A1
SCHEMBL16233178 0.79 TP53 (0.60) HCN4THRBLMNAHCN1ALDH1A1
SCHEMBL16233223 0.78 SLC6A5 (0.52) HCN4LMNASLC6A5HCN1ALDH1A1
SCHEMBL16233201 0.77 SLC6A5 (0.59) LMNASLC6A5
SCHEMBL5017330 0.76 SLC6A5 (0.74) THRBLMNASLC6A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9359346-B2 Benzamide derivative and use thereof VIVOZON, INC. (KR) 2016-06-07 US disclosed
US-9359346-B2 Benzamide derivative and use thereof VIVOZON, INC. (KR) 2016-06-07 US disclosed
US-20140336378-A1 NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF VIVOZON, INC. (KR) 2014-11-13 US disclosed
US-20140336378-A1 NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF VIVOZON, INC. (KR) 2014-11-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140336378-A1 NOVEL BENZAMIDE DERIVATIVE AND USE THEREOF TRPV1, TRPA1, TRPV5 TDP1 2300/4885HCN4 210/4885THRB 4691/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.