Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235515 | 0.68 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL16235405 | 0.66 | GPBAR1 (0.37) | ALDH1A1 | |
| SCHEMBL16235321 | 0.66 | ACLY (0.33) | ALDH1A1 | |
| SCHEMBL16235142 | 0.66 | GPBAR1 (0.34) | ALDH1A1 | |
| SCHEMBL19682808 | 0.63 | TRPV4 (0.47) | CCR4ALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL16235389 | 0.63 | HTT (0.30) | CCR4HTTSCN9A | |
| SCHEMBL16235739 | 0.63 | S100A9 (0.46) | CCR4ALDH1A1HPGDKDM4E | |
| SCHEMBL16235458 | 0.63 | ATF1 (0.35) | CCR4HPGDEDNRAHTTKDM4E | |
| SCHEMBL2116753 | 0.62 | ALDH1A1 (0.41) | CCR4ALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL20919257 | 0.61 | PDCD1LG2 (0.40) | ALDH1A1GAAHPGDSMN1; SMN2EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |