Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235054 | 0.86 | HTT (0.31) | MAPTHTT | |
| SCHEMBL16234970 | 0.74 | ALDH1A1 (0.31) | ALDH1A1MAPT | |
| SCHEMBL16235182 | 0.72 | AR (0.34) | ALDH1A1MAPTLMNAHTT | |
| SCHEMBL16235786 | 0.72 | S100A9 (0.41) | ALDH1A1 | |
| SCHEMBL16235383 | 0.71 | HTT (0.33) | HTT | |
| SCHEMBL16235389 | 0.67 | HTT (0.30) | HTT | |
| SCHEMBL16235234 | 0.67 | FLT1 (0.38) | ALDH1A1MAPTHTT | |
| SCHEMBL16235303 | 0.65 | HTT (0.32) | HTT | |
| SCHEMBL16234950 | 0.64 | HTT (0.33) | ALDH1A1MAPTHTT | |
| SCHEMBL16235348 | 0.62 | CCR4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |