Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9097174 | 0.80 | LMNA (0.48) | LMNAPOLBNPC1RAB9ANCOA3 | |
| SCHEMBL1102399 | 0.79 | LMNA (0.59) | LMNANPC1RAB9ANCOA3CYP2A6 | |
| SCHEMBL31732807 | 0.79 | LMNA (0.59) | LMNANPC1RAB9ANCOA3CYP2A6 | |
| SCHEMBL10545951 | 0.78 | LMNA (0.46) | LMNANPC1RAB9ANCOA3CYP2A6 | |
| Iodide SCHEMBL10722209 | 0.77 | LMNA (0.58) | LMNANPC1RAB9ANCOA3CYP2A6 | |
| SCHEMBL7073970 | 0.75 | LMNA (0.65) | LMNANPC1RAB9ANCOA3CYP2A6 | |
| SCHEMBL19099919 | 0.74 | LMNA (0.54) | LMNANPC1RAB9ANCOA3CYP2A6 | |
| SCHEMBL6638130 | 0.74 | LMNA (0.54) | LMNANPC1RAB9ANCOA3CYP2A6 | |
| SCHEMBL4265753 | 0.74 | LMNA (0.64) | LMNANPC1RAB9ANCOA3CYP2A6 | |
| SCHEMBL6748371 | 0.74 | LMNA (0.54) | LMNANPC1RAB9ANCOA3CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997015-B1 | PHENOXYETHYL DIHYDRO-1H-ISOQUINOLINE COMPOUNDS | LILLY CO ELI (US) | 2017-04-05 | — | — | EP | disclosed |
| US-9371289-B2 | Phenoxyethyl dihydro-1H-isoquinoline compounds | ELI LILLY AND COMPANY (US) | 2016-06-21 | — | — | US | disclosed |
| EP-2997015-A1 | PHENOXYETHYL DIHYDRO-1H-ISOQUINOLINE COMPOUNDS | Eli Lilly and Company (US) | 2016-03-23 | — | — | EP | disclosed |
| US-20160052889-A1 | PHENOXYETHYL DIHYDRO-1H-ISOQUINOLINE COMPOUNDS | JPMORGAN CHASE BANK, N.A., AS SUCCESSOR COLLATERAL AGENT | 2016-02-25 | — | — | US | disclosed |
| CN-105209438-A | Phenoxyethyl dihydro-1H-isoquinoline compounds | LILLY CO ELI | 2015-12-30 | — | — | CN | disclosed |
| WO-2014186218-A1 | PHENOXYETHYL DIHYDRO-1H-ISOQUINOLINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052889-A1 | PHENOXYETHYL DIHYDRO-1H-ISOQUINOLINE COMPOUNDS | REN, NHERF1, KCNH1 | LMNA 3301/4885POLB 2318/4885NPC1 182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.