Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1625944 | 1.00 | LMNA (0.39) | LMNACYP2C9CYP2C19GRIN1GRIN2B | |
| SCHEMBL1624004 | 0.82 | LMNA (0.37) | LMNATAAR1TSHRTACR1CTSL | |
| SCHEMBL1623869 | 0.82 | LMNA (0.37) | LMNATAAR1HRH4HRH3PDE4D | |
| SCHEMBL1623867 | 0.82 | LMNA (0.37) | LMNATAAR1HRH4HRH3PDE4D | |
| SCHEMBL1624002 | 0.82 | LMNA (0.37) | LMNATAAR1TSHRTACR1CTSL | |
| SCHEMBL1809933 | 0.78 | CTSL (0.45) | LMNACYP2C9CYP2C19GRIN1GRIN2B | |
| SCHEMBL13815948 | 0.76 | ALDH1A1 (0.46) | CYP2C9CYP2C19TSHRCTSLCTSB | |
| SCHEMBL4474785 | 0.76 | ALDH1A1 (0.46) | CYP2C9CYP2C19TSHRCTSLCTSB | |
| SCHEMBL582586 | 0.75 | TSHR (0.44) | LMNATAAR1HRH4HRH3TSHR | |
| SCHEMBL2993483 | 0.74 | ALDH1A1 (0.46) | CYP2C9CYP2C19TSHRCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928091-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA LTD. (CA) | 2011-04-19 | — | — | US | disclosed |
| US-20090093444-A1 | Cathepsin Cysteine Protease Inhibitors | MERCK FROSST CANADA LTD. (CA) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093444-A1 | Cathepsin Cysteine Protease Inhibitors | CTSB, CTSS, CTSZ | LMNA 2431/4885CYP2C9 4018/4885CYP2C19 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.