Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | IL1RN | P18510 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239526 | 0.89 | GAA (0.42) | HPGDGAAHTR6CA12CA1 | |
| SCHEMBL16239494 | 0.88 | BRD4 (0.39) | KDM1AALDH1A1SMN1; SMN2LMNAKEAP1 | |
| SCHEMBL16239807 | 0.86 | FFAR4 (0.45) | HPGDGAAHTR6CA12CA1 | |
| SCHEMBL16239989 | 0.86 | IMPDH2 (0.40) | HPGDGAAHTR6CA12CA1 | |
| SCHEMBL16240072 | 0.83 | CA12 (0.42) | GAACA12CA1CA2CA9 | |
| SCHEMBL2133243 | 0.83 | GAA (0.42) | HPGDGAAHTR6CA12CA1 | |
| SCHEMBL16239957 | 0.81 | MCOLN2 (0.39) | HPGDALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL16240086 | 0.81 | FFAR4 (0.48) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL16240087 | 0.81 | GPR119 (0.41) | GAACA12CA1CA2CA9 | |
| SCHEMBL16240075 | 0.81 | L3MBTL1 (0.45) | HPGDGAAALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |