Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | F11 | P03951 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239486 | 0.88 | HPGD (0.43) | BRD4KDM1AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16239477 | 0.88 | BRD4 (0.38) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL16239667 | 0.85 | KIF11 (0.40) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL16239481 | 0.85 | BRD4 (0.36) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL2135572 | 0.81 | F11 (0.43) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL16239521 | 0.80 | KEAP1 (0.42) | ALDH1A1KEAP1 | |
| SCHEMBL16254119 | 0.78 | F11 (0.42) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL2135784 | 0.78 | F11 (0.42) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL16240072 | 0.77 | CA12 (0.42) | BRD4ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL16239526 | 0.77 | GAA (0.42) | BRD4KDM1AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |