Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239807 | 0.89 | FFAR4 (0.45) | KDM1AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16240086 | 0.88 | FFAR4 (0.48) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16239799 | 0.88 | FFAR4 (0.45) | BRD4ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL16240123 | 0.87 | SLC22A12 (0.43) | BRD4ALDH1A1 | |
| SCHEMBL16239494 | 0.85 | BRD4 (0.39) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL16239477 | 0.84 | BRD4 (0.38) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL16239481 | 0.81 | BRD4 (0.36) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL2136517 | 0.80 | KIF11 (0.46) | KIF11BRD4CREBBPF11F7 | |
| SCHEMBL16254119 | 0.77 | F11 (0.42) | BRD4CREBBPOPRM1KDM1AF11 | |
| SCHEMBL2135572 | 0.75 | F11 (0.43) | BRD4CREBBPOPRM1KDM1AF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |