Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 11/20 | 0.35 |
| ▸ | F7 | P08709 | 11/20 | 0.35 |
| ▸ | F10 | P00742 | 10/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL16240210 | 0.85 | LMNA (0.37) | CCR5 | |
| SCHEMBL2135434 | 0.83 | PRKAG1 (0.37) | ATMPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL2136073 | 0.83 | PRKAG1 (0.37) | ATMPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL2135784 | 0.81 | F11 (0.42) | F11F7 | |
| Bicarbonate SCHEMBL16239828 | 0.81 | PRKAB2 (0.42) | ATMPRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL2135328 | 0.79 | PGR (0.44) | F11F7 | |
| SCHEMBL2134822 | 0.79 | F11 (0.36) | PRKAG1PRKAA1PRKAB1F11F7 | |
| SCHEMBL2729952 | 0.78 | F7 (0.45) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| Bicarbonate SCHEMBL16240209 | 0.78 | MLNR (0.36) | F11F7F10CYP11B1CYP11B2 | |
| Bicarbonate SCHEMBL16239474 | 0.77 | CCR5 (0.33) | CCR5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630124-B1 | TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2014-11-19 | — | — | EP | claimed |