Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | AHR | P35869 | 3/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27853993 | 0.90 | FAAH (0.47) | FAAHROCK2MAPK14LTA4HPARP1 | |
| SCHEMBL18926970 | 0.83 | HRH3 (0.55) | FAAHROCK2MAPK14LTA4HPARP1 | |
| SCHEMBL13293706 | 0.73 | FAAH (0.55) | FAAHROCK2MAPK14LTA4HHRH3 | |
| SCHEMBL14375335 | 0.72 | ACHE (0.62) | FAAHROCK2MAPK14PARP1MCHR1 | |
| SCHEMBL10696872 | 0.72 | ALDH1A1 (0.63) | HRH3ALDH1A1MAPT | |
| SCHEMBL27854002 | 0.70 | LMNA (0.47) | MAPK14PARP1MAPT | |
| SCHEMBL28791958 | 0.70 | DRD4 (0.45) | AHRALDH1A1 | |
| SCHEMBL3752475 | 0.70 | FAAH (0.70) | FAAHROCK2MAPK14PARP1TNK2 | |
| SCHEMBL3334754 | 0.70 | HRH3 (0.48) | MCHR1BACE1HRH3ALDH1A1MAPT | |
| SCHEMBL10701011 | 0.70 | ALDH1A1 (0.51) | HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254883-B1 | SUBSTITUTED INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2014-11-26 | — | — | EP | claimed |
| CN-102015683-A | Substituted indole derivatives | GRUENENTHAL GMBH | 2011-04-13 | — | — | CN | claimed |
| CN-102015683-A | Substituted indole derivatives | GRUENENTHAL GMBH | 2011-04-13 | — | — | CN | disclosed |