Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622506 | 0.85 | LMNA (0.58) | LMNAHTTKDM4EMAPK1GAA | |
| SCHEMBL13284389 | 0.84 | KDM4E (0.65) | LMNAHTTKDM4EMAPK1GAA | |
| SCHEMBL27854104 | 0.82 | LMNA (0.71) | LMNAHTTKDM4EMAPK1GAA | |
| SCHEMBL28791958 | 0.78 | DRD4 (0.45) | KDM4EJAK2DRD4HTR2A | |
| SCHEMBL23609411 | 0.77 | HTR6 (0.56) | LMNAHTTKDM4EMAPK1GAA | |
| SCHEMBL30099664 | 0.77 | HTR6 (0.56) | LMNAHTTKDM4EMAPK1GAA | |
| SCHEMBL23432525 | 0.75 | GAA (0.52) | LMNAHTTKDM4EMAPK1GAA | |
| SCHEMBL32691857 | 0.74 | GAA (0.50) | LMNAHTTKDM4EMAPK1GAA | |
| SCHEMBL28256631 | 0.73 | OPRM1 (0.55) | LMNAHTTKDM4EMAPK1GAA | |
| SCHEMBL16242410 | 0.70 | FAAH (0.46) | MAPTPARP1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015683-A | Substituted indole derivatives | GRUENENTHAL GMBH | 2011-04-13 | — | — | CN | claimed |
| CN-102015683-A | Substituted indole derivatives | GRUENENTHAL GMBH | 2011-04-13 | — | — | CN | disclosed |