Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 4/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 7/20 | 0.34 |
| ▸ | BRD2 | P25440 | 7/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 7/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16268761 | 0.86 | MEN1 (0.36) | L3MBTL1RXFP1TRPA1BRD4MAPT | |
| SCHEMBL20160086 | 0.81 | ATAD2 (0.36) | L3MBTL1BRD4BRD2BRD3CREBBP | |
| SCHEMBL20160237 | 0.81 | L3MBTL1 (0.33) | L3MBTL1BRD4BRD2BRD3 | |
| SCHEMBL16259902 | 0.79 | BRD4 (0.35) | BRD4BRD2BRD3CREBBPNPC1 | |
| SCHEMBL31155678 | 0.78 | L3MBTL1 (0.41) | L3MBTL1RXFP1TRPA1PRNPPABPC1 | |
| SCHEMBL16268588 | 0.78 | LMNA (0.39) | L3MBTL1RXFP1PRNPBRD4BRD2 | |
| SCHEMBL16268766 | 0.77 | L3MBTL1 (0.40) | L3MBTL1RXFP1TRPA1PRNPPABPC1 | |
| SCHEMBL16244913 | 0.76 | BRD3 (0.34) | BRD4BRD2BRD3CREBBPNPC1 | |
| SCHEMBL16267911 | 0.73 | RXFP1 (0.36) | RXFP1BRD4BRD2BRD3CREBBP | |
| SCHEMBL21227653 | 0.72 | CYP1A2 (0.41) | BRD4BRD2BRD3CREBBPNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709722-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233547-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |
| CN-110997670-B | [1,2,4] triazolo [4,3-a ] pyridyl substituted indole compounds | 百时美施贵宝公司 | 2022-11-01 | — | — | CN | disclosed |
| EP-3661934-B1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-01 | — | — | EP | disclosed |
| EP-3661934-B1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-01 | — | — | EP | disclosed |
| US-11130756-B2 | [1,2,4]Triazolo[4,3-A]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-09-28 | — | — | US | disclosed |
| US-11130756-B2 | [1,2,4]Triazolo[4,3-A]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200369661-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-11-26 | — | — | US | disclosed |
| US-20200369661-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-11-26 | — | — | US | disclosed |
| EP-3661934-A1 | [1,2,4]TRIAZOLO[4,3-a]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2020-06-10 | — | — | EP | disclosed |
| US-20160095843-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2016-04-07 | — | — | US | disclosed |
| US-20160095843-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2016-04-07 | — | — | US | disclosed |
| US-8975417-B2 | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | NOVARTIS AG (CH) | 2015-03-10 | — | — | US | disclosed |
| US-8975417-B2 | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | NOVARTIS AG (CH) | 2015-03-10 | — | — | US | disclosed |
| US-8975417-B2 | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | NOVARTIS AG (CH) | 2015-03-10 | — | — | US | disclosed |
| WO-2014191906-A1 | PYRAZOLO-PYRROLIDIN-4-ONE DERIVATIVES AS BET INHIBITORS AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2014-12-04 | — | — | WO | disclosed |
| WO-2014191896-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2014-12-04 | — | — | WO | disclosed |
| US-20140349990-A1 | Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease | NOVARTIS AG (CH) | 2014-11-27 | — | — | US | disclosed |
| US-20140349990-A1 | Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease | NOVARTIS AG (CH) | 2014-11-27 | — | — | US | disclosed |
| US-20140349990-A1 | Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease | NOVARTIS AG (CH) | 2014-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160095843-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | PKD1, PKD2, REN | L3MBTL1 4859/4885RXFP1 3158/4885TRPA1 651/4885 |
| US-11130756-B2 | [1,2,4]Triazolo[4,3-A]pyridinyl substituted indole compounds | TLR7, TLR1, TLR4 | L3MBTL1 4488/4885RXFP1 126/4885TRPA1 78/4885 |
| US-20140349990-A1 | Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease | PKD1, PKD2, REN | L3MBTL1 4860/4885RXFP1 3117/4885TRPA1 665/4885 |
| US-20200369661-A1 | [1,2,4]TRIAZOLO[4,3-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | TLR7, TLR1, TLR4 | L3MBTL1 4488/4885RXFP1 126/4885TRPA1 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.