Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 4/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.35 |
| ▸ | RELA | Q04206 | 4/20 | 0.35 |
| ▸ | FOS | P01100 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | TKT | P29401 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | HEXA | P06865 | 1/20 | 0.30 |
| ▸ | HEXB | P07686 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345073 | 0.83 | FOS (0.30) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL31416631 | 0.78 | HEXA (0.36) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL31416682 | 0.78 | JUN (0.32) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL14533192 | 0.76 | TRPV3 (0.33) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL14809757 | 0.76 | GABRP (0.45) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL17703517 | 0.75 | ALDH1A1 (0.34) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL2116606 | 0.74 | KDM4E (0.38) | — | |
| SCHEMBL17472689 | 0.73 | S100A9 (0.42) | NFKB1 | |
| Formamide SCHEMBL28472309 | 0.73 | TKT (0.34) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL16741140 | 0.72 | JUN (0.41) | JUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-B1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2016-02-03 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |