Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.45 |
| ▸ | GABRD | O14764 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.45 |
| ▸ | GABRE | P78334 | 2/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.45 |
| ▸ | JUN | P05412 | 5/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.43 |
| ▸ | RELA | Q04206 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844275 | 0.82 | JUN (0.58) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL2352570 | 0.78 | HPGD (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3283505 | 0.76 | ASPH (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15718403 | 0.76 | GABRP (0.50) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8544671 | 0.76 | XPO1 (0.42) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL16248176 | 0.76 | JUN (0.35) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL4415725 | 0.75 | KEAP1 (0.44) | JUNNFKB1NFKB2RELAFOS | |
| SCHEMBL28044658 | 0.75 | ASPH (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10865607 | 0.75 | JUN (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL22868013 | 0.74 | POLB (0.46) | JUNNFKB1NFKB2RELAFOS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013043826-A1 | TRICYCLIC COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | ABBVIE INC. (US) | 2013-03-28 | — | — | WO | disclosed |