Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16255380 | 0.90 | GABRA1 (0.38) | PTGDRPTGDR2KDM4ELMNAGABRA1 | |
| SCHEMBL195146 | 0.84 | ALDH1A1 (0.43) | KDM4ELMNAMAPTALDH1A1MEN1 | |
| SCHEMBL194352 | 0.79 | ALDH1A1 (0.38) | PTGDRPTGDR2KDM4EGABRA1GABRB2 | |
| SCHEMBL16393687 | 0.79 | ELANE (0.35) | PTGDRPTGDR2KDM4EGABRA1GABRB2 | |
| SCHEMBL21192545 | 0.79 | ALOX5 (0.32) | PTGDRPTGDR2GABRA1GABRB2CNR2 | |
| SCHEMBL7608902 | 0.78 | ESR1 (0.36) | GABRA1GABRB2 | |
| SCHEMBL29463283 | 0.77 | GABRA1 (0.56) | KDM4ELMNAGABRA1GABRB2MAPT | |
| SCHEMBL29414940 | 0.77 | GABRA1 (0.56) | KDM4ELMNAGABRA1GABRB2MAPT | |
| SCHEMBL1055347 | 0.77 | GABRA1 (0.56) | KDM4ELMNAGABRA1GABRB2MAPT | |
| SCHEMBL14591648 | 0.76 | PTPN1 (0.34) | PTGDRPTGDR2GABRA1GABRB2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889744-B2 | Bis-trifluoromethyl honokiol analogs and their use in treating cancers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-11-18 | — | — | US | disclosed |