Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1878222 | 0.82 | CXCL8 (0.51) | CXCL8KDM4EALDH1A1HPGDAKR1C3 | |
| SCHEMBL31445485 | 0.81 | RIPK1 (0.38) | L3MBTL1RIPK1HPGDAKR1C3AKR1C2 | |
| SCHEMBL807519 | 0.79 | DYRK1A (0.41) | L3MBTL1RIPK1ALDH1A1HPGDGAA | |
| SCHEMBL31445554 | 0.78 | KMT2A (0.44) | KDM4EALDH1A1HPGDGAAAKR1C3 | |
| SCHEMBL3060819 | 0.76 | CXCL8 (0.46) | CXCL8KDM4EALDH1A1HPGDAKR1C3 | |
| SCHEMBL11139560 | 0.75 | CXCL8 (0.45) | CXCL8L3MBTL1RIPK1KDM4EALDH1A1 | |
| SCHEMBL18896405 | 0.73 | L3MBTL1 (0.40) | L3MBTL1RIPK1KDM4EALDH1A1HPGD | |
| SCHEMBL3045697 | 0.73 | CXCL8 (0.44) | CXCL8ALDH1A1AKR1C3AKR1C2PTGS1 | |
| SCHEMBL7050570 | 0.73 | L3MBTL1 (0.45) | CXCL8L3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL31561697 | 0.73 | L3MBTL1 (0.45) | CXCL8L3MBTL1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004061-B1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | LILLY CO ELI (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-3004061-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND CO. (US) | 2016-04-13 | — | — | EP | disclosed |
| US-8962654-B2 | 3,4-dihydroisoquinolin-2(1H)-yl compounds | ELI LILLY AND COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| WO-2014193781-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-12-04 | — | — | WO | disclosed |
| US-20140357664-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2014-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357664-A1 | 3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS | PARK7, SNCA, COMT | CXCL8 3587/4885L3MBTL1 3705/4885RIPK1 1851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.